4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
CAS No.:856660-75-8
Molecular Formula:C₄₉H₆₄N₂O₉SSi
Molecular Weight:885.207
Hs Code.:

4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(<i>tert</i>-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid <i>tert</i>-butyl ester

Synonyms:4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Chemical Property of 4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of 4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 16 articles about 4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 856660-74-7
4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 74-88-4
methyl iodide

: 856660-75-8
4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1002/ejoc.200400709

Reference yield:

: 1155-62-0
N-benzyloxycarbonyl-L-glutamic acid

: 856660-75-8
4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 98 percent / BF₃*OEt₂

2: 79 percent / LiBH₄ / methanol; tetrahydrofuran / 4 h / 0 °C

3: 88 percent / pTsOH / CH₂Cl₂ / 24 h / 20 °C

4: 27.4 g / Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

5: tetrahydrofuran / 1 h / 0 - 20 °C

6: 31.4 g / magnesium monoperoxy phthalate / ethanol / 0 °C

7: 24.1 g / CeCl₃*7H₂O; (COOH)2 / acetonitrile / 20 °C

8: 38.6 g / imidazole / dimethylformamide / 2 h / 20 °C

9: 85 percent / nBuLi / tetrahydrofuran; hexane / 2.33 h / -78 - 20 °C

10: 95 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 4 h / 20 °C

11: 97 percent / K₂CO₃ / dimethylformamide / 8 h / 20 °C

With 1H-imidazole; lithium borohydride; n-butyllithium; cerium(III) chloride; boron trifluoride diethyl etherate; oxalic acid; potassium carbonate; toluene-4-sulfonic acid; magnesium monoperoxyphthalate hexahydrate; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200400709

Reference yield:

: 67436-17-3
dimethyl (S)-N-(benzyloxycarbonyl)glutamate

: 856660-75-8
4-[4-benzenesulfonyl-7-benzyloxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-4-methyl-3-oxo-octyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 79 percent / LiBH₄ / methanol; tetrahydrofuran / 4 h / 0 °C

2: 88 percent / pTsOH / CH₂Cl₂ / 24 h / 20 °C

3: 27.4 g / Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

4: tetrahydrofuran / 1 h / 0 - 20 °C

5: 31.4 g / magnesium monoperoxy phthalate / ethanol / 0 °C

6: 24.1 g / CeCl₃*7H₂O; (COOH)2 / acetonitrile / 20 °C

7: 38.6 g / imidazole / dimethylformamide / 2 h / 20 °C

8: 85 percent / nBuLi / tetrahydrofuran; hexane / 2.33 h / -78 - 20 °C

9: 95 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 4 h / 20 °C

10: 97 percent / K₂CO₃ / dimethylformamide / 8 h / 20 °C

With 1H-imidazole; lithium borohydride; n-butyllithium; cerium(III) chloride; oxalic acid; potassium carbonate; toluene-4-sulfonic acid; magnesium monoperoxyphthalate hexahydrate; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200400709