(R)-1-(2-amino-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-3-amine

Base Information

Chemical Name:(R)-1-(2-amino-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-3-amine
CAS No.:884603-46-7
Molecular Formula:C₁₄H₂₀F₃N₃
Molecular Weight:287.328
Hs Code.:

Synonyms:(R)-1-(2-amino-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-3-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(2-amino-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-3-amine

Chemical Property:

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Technology Process of (R)-1-(2-amino-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-3-amine

There total 2 articles about (R)-1-(2-amino-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-N,N-dimethyl-1-(2-nitro-4-(trifluoromethyl)phenyl)piperidin-3-amine

: 884603-46-7
(R)-1-(2-amino-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-3-amine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; water; under 1520 Torr;
DOI:10.1021/jm061112p

Reference yield:

: 884603-46-7
(R)-1-(2-amino-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-3-amine

Guidance literature:

Reference yield:

: 884603-46-7
(R)-1-(2-amino-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-3-amine

: N-[2-(3-dimethylamino-piperidin-1-yl)-5-trifluoromethyl-phenyl]-5-ethynyl-2-fluoro-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

2.1: Et₃N / PdCl₂(PPh₃)2; CuI / acetonitrile / 20 °C

2.2: K₂CO₃; MeOH / 1.5 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; acetonitrile; 2.1: Sonogashira coupling;
DOI:10.1021/jm061112p