(R)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

Base Information

Chemical Name:(R)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide
CAS No.:926036-47-7
Molecular Formula:C₂₁H₂₂F₄IN₃O
Molecular Weight:535.323
Hs Code.:

Synonyms:(R)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

Chemical Property:

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Technology Process of (R)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

There total 3 articles about (R)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-N,N-dimethyl-1-(2-nitro-4-(trifluoromethyl)phenyl)piperidin-3-amine

: 926036-47-7
(R)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol; H₂O / 1520 Torr

2: iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1021/jm061112p

Reference yield:

: 186584-73-6
2-fluoro-5-iodobenzoyl chloride

: 884603-46-7
(R)-1-(2-amino-4-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-3-amine

: 926036-47-7
(R)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm061112p

Reference yield:

: 124700-41-0
2-fluoro-5-iodobenzoic acid

: 926036-47-7
(R)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm061112p