N-(3'-bromopropyl)-2-phenylacetamide

Base Information

• Chemical Name: N-(3'-bromopropyl)-2-phenylacetamide
• CAS No.: 910794-36-4
• Molecular Formula: C₁₁H₁₄BrNO
• Molecular Weight: 256.142
• Mol file: 910794-36-4.mol

Synonyms:N-(3'-bromopropyl)-2-phenylacetamide

Chemical Property of N-(3'-bromopropyl)-2-phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(3'-bromopropyl)-2-phenylacetamide

There total 3 articles about N-(3'-bromopropyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-bromopropylamine hydrochloride (5003-71-4) + phenylacetyl chloride (103-80-0) → N-(3'-bromopropyl)-2-phenylacetamide (910794-36-4)

Guidance literature:

3-bromopropylamine hydrochloride; With sodium carbonate; In dichloromethane; water; at 0 ℃; for 0.0833333h; Inert atmosphere;

phenylacetyl chloride; In dichloromethane; water; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c4cc03094j

Reference yield: 86.0%

phenylacetic acid (103-82-2) + 3-bromopropylamine hydrochloride (5003-71-4) → N-(3'-bromopropyl)-2-phenylacetamide (910794-36-4)

Guidance literature:

With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; at -20 - 25 ℃; Inert atmosphere;

DOI:10.1021/jo101955q

Reference yield:

3-bromopropylamine hydrochloride (5003-71-4) + phenylacetyl chloride (103-80-0) → 2-benzyl-5,6-dihydro-4H-1,3-oxazine hydrobromide + N-(3'-bromopropyl)-2-phenylacetamide (910794-36-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.5h; Title compound not separated from byproducts;

DOI:10.1016/j.tetlet.2006.06.138

upstream raw materials:

3-bromopropylamine hydrochloride

phenylacetyl chloride

phenylacetic acid

Downstream raw materials:

5'-deoxy-5'-[3-(2-phenylacetamido)propylthio]adenosine

2-benzyl-Δ²-oxazine

Refernces

• 1、 Kai, Kenji,Fujii, Hiroki,Ikenaka, Rui,Akagawa, Mitsugu,Hayashi, Hideo. "An acyl-SAM analog as an affinity ligand for identifying quorum sensing signal synthases". supporting information. p. 8586 - 8589. Retrieved 2014/07/22.