1-Methyl-4-(2,2,2-trifluoro-1-methyl-ethyl)benzene

Base Information

• Chemical Name: 1-Methyl-4-(2,2,2-trifluoro-1-methyl-ethyl)benzene
• CAS No.: 1204295-78-2
• Molecular Formula: C₁₀H₁₁F₃
• Molecular Weight: 188.193
• Mol file: 1204295-78-2.mol

Synonyms:4-methyl-(2,2,2-trifluoro-1-methylethyl)benzene

Chemical Property of 1-Methyl-4-(2,2,2-trifluoro-1-methyl-ethyl)benzene

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

1-Methyl-4-(2,2,2-trifluoro-1-methyl-ethyl)benzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methyl-4-(2,2,2-trifluoro-1-methyl-ethyl)benzene

There total 6 articles about 1-Methyl-4-(2,2,2-trifluoro-1-methyl-ethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-methyl-4-(3,3,3-trifluoroprop-1-en-2-yl)benzene (69843-09-0) → 4-methyl-(2,2,2-trifluoro-1-methylethyl)benzene (1204295-78-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 3h;

DOI:10.1039/c7cc04377e

Reference yield: 75.0%

1-(1-chloroethyl)-4-methylbenzene (2362-36-9) + (trifluoromethyl)trimethylsilane (81290-20-2) → 4-methyl-(2,2,2-trifluoro-1-methylethyl)benzene (1204295-78-2)

Guidance literature:

With potassium fluoride; copper(I) thiophene-2-carboxylate; In tetrahydrofuran; at 60 ℃; for 48h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4ob00957f

Reference yield: 68.0%

1-methyl-4-(3,3,3-trifluoroprop-1-en-2-yl)benzene (69843-09-0) → 4-methyl-(2,2,2-trifluoro-1-methylethyl)benzene (1204295-78-2) + 4-methyl-β,β-difluoro-α-methylstyrene

Guidance literature:

With methanol; In acetonitrile; at 20 ℃; for 24h; Reagent/catalyst; UV-irradiation; Inert atmosphere;

DOI:10.1039/c7cc04377e

upstream raw materials:

C₉H₁₁Cl

(trifluoromethyl)trimethylsilane

1-(1-chloroethyl)-4-methylbenzene

2,2,2-trifluoro-1-(p-tolyl)ethanone

Refernces

• 1、 Miyake, Yoshihiro,Ota, Shin-Ichi,Shibata, Masashi,Nakajima, Kazunari,Nishibayashi, Yoshiaki. "Copper-catalyzed nucleophilic trifluoromethylation of benzylic chlorides". supporting information. p. 5594 - 5596. Retrieved 2014/07/22.