N-((2S,3R)-3-(1,3-dioxolan-2-yl)-2-phenylpentyl)-4-nitrobenzenesulfonamide

Base Information

Chemical Name:N-((2S,3R)-3-(1,3-dioxolan-2-yl)-2-phenylpentyl)-4-nitrobenzenesulfonamide
CAS No.:1433543-63-5
Molecular Formula:C₂₀H₂₄N₂O₆S
Molecular Weight:420.486
Hs Code.:

Synonyms:N-((2S,3R)-3-(1,3-dioxolan-2-yl)-2-phenylpentyl)-4-nitrobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2S,3R)-3-(1,3-dioxolan-2-yl)-2-phenylpentyl)-4-nitrobenzenesulfonamide

Chemical Property:

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Technology Process of N-((2S,3R)-3-(1,3-dioxolan-2-yl)-2-phenylpentyl)-4-nitrobenzenesulfonamide

There total 4 articles about N-((2S,3R)-3-(1,3-dioxolan-2-yl)-2-phenylpentyl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1433543-53-3
(2S,3R)-3-(1,3-dioxolan-2-yl)-2-phenylpentan-1-amine

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1433543-63-5
N-((2S,3R)-3-(1,3-dioxolan-2-yl)-2-phenylpentyl)-4-nitrobenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1002/chem.201202409

Reference yield:

: 102-96-5
(2-nitroethenyl)benzene

: 1433543-63-5
N-((2S,3R)-3-(1,3-dioxolan-2-yl)-2-phenylpentyl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline / dimethyl sulfoxide / 12 h / 25 °C / Sealed tube

2: toluene-4-sulfonic acid / toluene / 20 h / Reflux; Inert atmosphere

3: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / -20 - 0 °C

4: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; toluene-4-sulfonic acid; triethylamine; L-proline; In methanol; dichloromethane; dimethyl sulfoxide; toluene; 1: |Michael Addition;
DOI:10.1002/chem.201202409

Reference yield:

: 1433543-43-1
2-((2S,3R)-1-nitro-2-phenylpentan-3-yl)-1,3-dioxolane

: 1433543-63-5
N-((2S,3R)-3-(1,3-dioxolan-2-yl)-2-phenylpentyl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / -20 - 0 °C

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; triethylamine; In methanol; dichloromethane;
DOI:10.1002/chem.201202409