(R)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid tert-butyl ester

Base Information

Chemical Name:(R)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid tert-butyl ester
CAS No.:143381-54-8
Molecular Formula:C₂₂H₃₅NO₇
Molecular Weight:425.522
Hs Code.:

Synonyms:(R)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid tert-butyl ester

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Technology Process of (R)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid tert-butyl ester

There total 1 articles about (R)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 139308-00-2
(4S,5S)-4,5-Dimethoxymethyl-2-(N-p-methoxyphenyl)iminomethyl-2-methyl-1,3-dioxolane

: C₆H₁₁O₂^(1-)*Cl^(1-)*Zn⁽²⁺⁾

: 143381-53-7
(S)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid tert-butyl ester

: 143381-54-8
(R)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1246/cl.1992.1349

Reference yield: 88.0%

: 143381-54-8
(R)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid tert-butyl ester

: 143381-58-2
(R)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; Ambient temperature;
DOI:10.1246/cl.1992.1349

Reference yield:

: 143381-54-8
(R)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-(4-methoxy-phenylamino)-propionic acid tert-butyl ester

: 139308-12-6
(R)-4-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-1-(4-methoxy-phenyl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

2: 65 percent / triphenylphosphine-dipyridyl disulfide / acetonitrile / 55 °C

With triphenylphosphine-dipyridyl disulfide; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1246/cl.1992.1349