139308-00-2Relevant articles and documents
A stereodivergent construction of β-lactam skeletons via condensation of ester enolates and a chiral imine
Fujisawa, Tamotsu,Ukaji, Yutaka,Noro, Tomohiro,Date, Kengo,Shimizu, Makoto
, p. 7563 - 7566 (1991)
Diastereofacial selectivity in an addition reaction of ester enolates to a chiral imine with 1,3-dioxolane, derived from (S,S)-1,4-dimethoxy-2,3-butanediol as a chiral auxiliary, could be fully regulated by the appropriate selection of metal enolates used. Addition of the lithium enolates provided (4S)-β-lactams, while the corresponding (4R)-β-lactams were obtained by the condensation of titanium enolates with the chiral imine.