tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

Base Information

• Chemical Name: tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate
• CAS No.: 1593269-74-9
• Molecular Formula: C₃₃H₄₀N₂O₆
• Molecular Weight: 560.69
• Mol file: 1593269-74-9.mol

Synonyms:tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

Chemical Property of tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

There total 5 articles about tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C38H46N2O9 → tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate (1593269-74-9)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1248/cpb.c13-00513

Reference yield:

C33H38N2O7 (1593269-73-8) → tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate (1593269-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methyl-morpholine / tetrahydrofuran; dichloromethane / 0.25 h / -40 °C

2: sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; In tetrahydrofuran; dichloromethane;

DOI:10.1248/cpb.c13-00513

Reference yield:

ethyl 4-(bromomethyl)-2-phenyl-1,3-oxazole-5-carboxylate (189271-78-1) → tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate (1593269-74-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 40 °C

2: sodium hydroxide / tetrahydrofuran; water / 73.5 h / 20 - 50 °C

3: 4-methyl-morpholine / tetrahydrofuran; dichloromethane / 0.25 h / -40 °C

4: sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.c13-00513

upstream raw materials:

C₃₃H₃₈N₂O₇

ethyl 4-(bromomethyl)-2-phenyl-1,3-oxazole-5-carboxylate

ethyl 4-{[{4-[(1-tert-butoxy-2-methyl-1-oxopropan-2yl) oxy]-3,5-dimethylbenzyl}(furan-2-ylmethyl) amino] methyl}-2-phenyl-1,3-oxazole-5-carboxylate

Ethyl 4-methyl-2-phenyloxazole-5-carboxylate

Downstream raw materials:

2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid