2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

Base Information

• Chemical Name: 2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid
• CAS No.: 1593269-84-1
• Molecular Formula: C₂₉H₃₂N₂O₆
• Molecular Weight: 504.583
• Mol file: 1593269-84-1.mol

Synonyms:2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

Chemical Property of 2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid

There total 6 articles about 2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate (1593269-74-9) → 2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid (1593269-84-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

DOI:10.1248/cpb.c13-00513

Reference yield:

C38H46N2O9 → 2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid (1593269-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

With hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1248/cpb.c13-00513

Reference yield:

C33H38N2O7 (1593269-73-8) → 2-(4-{[{[2-phenyl-5-(hydroxymethyl)-1,3-oxazol-4-yl]-methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoic acid (1593269-84-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methyl-morpholine / tetrahydrofuran; dichloromethane / 0.25 h / -40 °C

2: sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1248/cpb.c13-00513

upstream raw materials:

C₃₃H₃₈N₂O₇

ethyl 4-(bromomethyl)-2-phenyl-1,3-oxazole-5-carboxylate

ethyl 4-{[{4-[(1-tert-butoxy-2-methyl-1-oxopropan-2yl) oxy]-3,5-dimethylbenzyl}(furan-2-ylmethyl) amino] methyl}-2-phenyl-1,3-oxazole-5-carboxylate

tert-butyl 2-(4-{[{[2-phenyl-5-(dimethylcarbamoyl)-1,3-oxazol-4-yl]methyl}(furan-2-ylmethyl)amino]methyl}-2,6-dimethylphenoxy)-2-methylpropanoate