1,6-di-tert-butyldimethylsilyl 4-O-(benzyloxycarbonyl)-2-deoxy-3-O-hexanoyl-2-(hexanoylamino)-β-D-glucopyranoside

Base Information

Chemical Name:1,6-di-tert-butyldimethylsilyl 4-O-(benzyloxycarbonyl)-2-deoxy-3-O-hexanoyl-2-(hexanoylamino)-β-D-glucopyranoside
CAS No.:506441-95-8
Molecular Formula:C₃₈H₆₇NO₉Si₂
Molecular Weight:738.122
Hs Code.:

Synonyms:1,6-di-tert-butyldimethylsilyl 4-O-(benzyloxycarbonyl)-2-deoxy-3-O-hexanoyl-2-(hexanoylamino)-β-D-glucopyranoside

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Chemical Property of 1,6-di-tert-butyldimethylsilyl 4-O-(benzyloxycarbonyl)-2-deoxy-3-O-hexanoyl-2-(hexanoylamino)-β-D-glucopyranoside

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Technology Process of 1,6-di-tert-butyldimethylsilyl 4-O-(benzyloxycarbonyl)-2-deoxy-3-O-hexanoyl-2-(hexanoylamino)-β-D-glucopyranoside

There total 11 articles about 1,6-di-tert-butyldimethylsilyl 4-O-(benzyloxycarbonyl)-2-deoxy-3-O-hexanoyl-2-(hexanoylamino)-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 506441-96-9
1,6-di-tert-butyldimethylsilyl 2-deoxy-3-O-hexanoyl-2-(hexanoylamino)-β-D-glucopyranoside

: 506441-95-8
1,6-di-tert-butyldimethylsilyl 4-O-(benzyloxycarbonyl)-2-deoxy-3-O-hexanoyl-2-(hexanoylamino)-β-D-glucopyranoside

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ja0284456

Reference yield:

: 2051-49-2
n-hexanoic anhydride

: 506441-95-8
1,6-di-tert-butyldimethylsilyl 4-O-(benzyloxycarbonyl)-2-deoxy-3-O-hexanoyl-2-(hexanoylamino)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂ / 8 h

2: 5.13 g / PPTS; MeOH / 3 h / Heating

3: 91 percent / imidazole / acetonitrile / 4 h

4: 71 percent / DMAP / CH₂Cl₂ / 16 h / 20 °C

With pyridine; 1H-imidazole; methanol; dmap; pyridinium p-toluenesulfonate; In dichloromethane; acetonitrile;
DOI:10.1021/ja0284456

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 506441-95-8
1,6-di-tert-butyldimethylsilyl 4-O-(benzyloxycarbonyl)-2-deoxy-3-O-hexanoyl-2-(hexanoylamino)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / imidazole / acetonitrile / 4 h

2: 71 percent / DMAP / CH₂Cl₂ / 16 h / 20 °C

With 1H-imidazole; dmap; In dichloromethane; acetonitrile;
DOI:10.1021/ja0284456