(S)-Quinolin-4-yl-((1S,2S,4S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with (R)-2,2-diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid

Base Information

Chemical Name:(S)-Quinolin-4-yl-((1S,2S,4S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with (R)-2,2-diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid
CAS No.:88082-53-5
Molecular Formula:C₁₉H₂₂N₂O*C₁₉H₂₂O₂Si
Molecular Weight:604.864
Hs Code.:

(S)-Quinolin-4-yl-((1S,2S,4S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with (R)-2,2-diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid

Synonyms:(S)-Quinolin-4-yl-((1S,2S,4S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with (R)-2,2-diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid

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Chemical Property of (S)-Quinolin-4-yl-((1S,2S,4S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with (R)-2,2-diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid

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Technology Process of (S)-Quinolin-4-yl-((1S,2S,4S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with (R)-2,2-diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid

There total 2 articles about (S)-Quinolin-4-yl-((1S,2S,4S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with (R)-2,2-diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7150-12-1
2,2-diphenyl-cyclopropanecarboxylic acid

: 88082-53-5
(S)-Quinolin-4-yl-((1S,2S,4S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with (R)-2,2-diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, 0 deg C, 3 h; 2.) THF, overnight, r.t.

2: acetone; ethanol

With lithium diisopropyl amide; In ethanol; acetone;
DOI:10.1021/ja00314a014