(1R)-2,2-Diphenyl-1-(trimethylsilyl)cyclopropane-1-carboxylic acid

Base Information

• Chemical Name: (1R)-2,2-Diphenyl-1-(trimethylsilyl)cyclopropane-1-carboxylic acid
• CAS No.: 88082-48-8
• Molecular Formula: C19H22O2Si
• Molecular Weight: 310.468
• DSSTox Substance ID: DTXSID20529905
• Wikidata: Q82400664

Synonyms:88082-48-8;(1R)-2,2-Diphenyl-1-(trimethylsilyl)cyclopropane-1-carboxylic acid;(R)-2,2-Diphenyl-1-(trimethylsilyl)cyclopropanecarboxylic acid;DTXSID20529905

Chemical Property of (1R)-2,2-Diphenyl-1-(trimethylsilyl)cyclopropane-1-carboxylic acid

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 310.138906475
• Heavy Atom Count: 22
• Complexity: 409

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C[Si](C)(C)C1(CC1(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O
• Isomeric SMILES: C[Si](C)(C)[C@@]1(CC1(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O

Technology Process of (1R)-2,2-Diphenyl-1-(trimethylsilyl)cyclopropane-1-carboxylic acid

There total 1 articles about (1R)-2,2-Diphenyl-1-(trimethylsilyl)cyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + 2,2-diphenyl-cyclopropanecarboxylic acid (7150-12-1) → 2,2-Diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid (88082-48-8) + (S)-2,2-Diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, 0 deg C, 3 h; 2.) THF, overnight, r.t.;

DOI:10.1021/ja00314a014

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2,2-Diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid (88082-48-8) → (R)-2,2-Diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid methyl ester (88035-81-8)

Guidance literature:

In diethyl ether;

DOI:10.1021/ja00314a014

Reference yield: 59.0%

2,2-Diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid (88082-48-8) → 1-bromo-2,2-diphenyl-1-(trimethylsilyl)cyclopropane (88056-68-2)

Guidance literature:

With bromine; mercury(II) oxide; In tetrachloromethane; for 6h; Heating;

DOI:10.1021/ja00314a014

upstream raw materials:

chloro-trimethyl-silane

2,2-diphenyl-cyclopropanecarboxylic acid

Downstream raw materials:

(R)-2,2-Diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid methyl ester

(S)-Quinolin-4-yl-((1S,2S,4S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with (R)-2,2-diphenyl-1-trimethylsilanyl-cyclopropanecarboxylic acid

1-bromo-2,2-diphenyl-1-(trimethylsilyl)cyclopropane

(-)-(R)-2,2-diphenyl-1-methyl-1-(trimethylsilyl)cyclopropane

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