Technology Process of N-(pyridin-4-yl)-7-(3-(trifluoromethyl)phenyl)-3,4-dihydropyrido[3,2-b][1,4]oxazepine-5(2H)-carboxamide
There total 6 articles about N-(pyridin-4-yl)-7-(3-(trifluoromethyl)phenyl)-3,4-dihydropyrido[3,2-b][1,4]oxazepine-5(2H)-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
bis(trichloromethyl) carbonate; 7-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazepine;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 0.5h;
4-aminopyridine;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium methylate; bromine / methanol / 0.5 h / 0 °C
1.2: 0.17 h / 0 °C
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2.5 h / 0 - 20 °C
3.1: acetic acid; iron / 2 h / 90 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 100 °C
5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere
6.1: triethylamine / dichloromethane / 0.5 h / 20 °C
6.2: 20 °C
With
di-isopropyl azodicarboxylate; bromine; sodium methylate; iron; sodium hydride; caesium carbonate; acetic acid; triethylamine; triphenylphosphine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2.5 h / 0 - 20 °C
2.1: acetic acid; iron / 2 h / 90 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 100 °C
4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 0.5 h / 20 °C
5.2: 20 °C
With
di-isopropyl azodicarboxylate; iron; sodium hydride; caesium carbonate; acetic acid; triethylamine; triphenylphosphine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;
