rac-2,6,6-trimethyl-1-(trimethylsilylethynyl)cyclohex-2-en-1-ol

Base Information

Chemical Name:rac-2,6,6-trimethyl-1-(trimethylsilylethynyl)cyclohex-2-en-1-ol
CAS No.:817203-16-0
Molecular Formula:C₁₄H₂₄OSi
Molecular Weight:236.429
Hs Code.:

Synonyms:rac-2,6,6-trimethyl-1-(trimethylsilylethynyl)cyclohex-2-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-2,6,6-trimethyl-1-(trimethylsilylethynyl)cyclohex-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of rac-2,6,6-trimethyl-1-(trimethylsilylethynyl)cyclohex-2-en-1-ol

There total 1 articles about rac-2,6,6-trimethyl-1-(trimethylsilylethynyl)cyclohex-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 20013-73-4
2,6,6-trimethylcyclohex-2-en-1-one

: 1066-54-2
trimethylsilylacetylene

: 817203-16-0
rac-2,6,6-trimethyl-1-(trimethylsilylethynyl)cyclohex-2-en-1-ol

Guidance literature:: trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

2,6,6-trimethylcyclohex-2-en-1-one; In tetrahydrofuran; hexane; at -78 - 0 ℃;
DOI:10.1039/b411585f

Reference yield: 67.0%

: 817203-16-0
rac-2,6,6-trimethyl-1-(trimethylsilylethynyl)cyclohex-2-en-1-ol

: 817203-17-1
2,4,4-trimethyl-3-(trimethylsilylethynyl)cyclohex-2-en-1-one

Guidance literature:: With silica gel; pyridinium chlorochromate; In dichloromethane; at 25 ℃; for 4h;
DOI:10.1039/b411585f

Reference yield:

: 817203-16-0
rac-2,6,6-trimethyl-1-(trimethylsilylethynyl)cyclohex-2-en-1-ol

: 3-(1-iodoethen-1-yl)-2,4,4-trimethylcyclohex-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 67 percent / PCC; silica gel / CH₂Cl₂ / 4 h / 25 °C

2.1: 70 percent / n-Bu₄NF / tetrahydrofuran / 0.25 h / 0 °C

3.1: n-Bu₃SnH / PdCl₂(PPh₃)2 / tetrahydrofuran / 0.17 h / 25 °C

3.2: 73 percent / I₂ / tetrahydrofuran; CH₂Cl₂ / 1 h / 25 °C

With tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; silica gel; pyridinium chlorochromate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b411585f