[4-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Base Information

• Chemical Name: [4-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone
• CAS No.: 185415-90-1
• Molecular Formula: C₃₀H₃₁NO₄S
• Molecular Weight: 501.646

Synonyms:[4-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Chemical Property of [4-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Chemical Property:

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Technology Process of [4-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

There total 3 articles about [4-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-methoxyphenyl magnesium bromide (13139-86-1) + (2-Dimethylamino-4-methoxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone (185415-69-4) → [4-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone (185415-90-1)

Guidance literature:

In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1021/jm9606352

Reference yield:

(4-Methoxy-benzo[b]thiophen-2-yl)-dimethyl-amine → [4-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone (185415-90-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / chlorobenzene / 9 h / 100 - 105 °C

2: 60 percent / tetrahydrofuran / 1.5 h / Ambient temperature

In tetrahydrofuran; chlorobenzene;

DOI:10.1021/jm9606352

Reference yield:

4-[2-(piperidin-1-yl)ethoxy]benzoyl chloride hydrochloride → [4-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone (185415-90-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / chlorobenzene / 9 h / 100 - 105 °C

2: 60 percent / tetrahydrofuran / 1.5 h / Ambient temperature

In tetrahydrofuran; chlorobenzene;

DOI:10.1021/jm9606352

upstream raw materials:

4-methoxyphenyl magnesium bromide

(2-Dimethylamino-4-methoxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Downstream raw materials:

[4-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

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