N-phenyl-3,5-bis(trifluoromethyl)aniline

Base Information

Chemical Name:N-phenyl-3,5-bis(trifluoromethyl)aniline
CAS No.:23917-96-6
Molecular Formula:C₁₄H₉F₆N
Molecular Weight:305.223
Hs Code.:
European Community (EC) Number:664-890-8
Nikkaji Number:J3.178.338K

Synonyms:N-phenyl-3,5-bis(trifluoromethyl)aniline;3,5-Bis(trifluoromethyl)diphenylamine;23917-96-6;SCHEMBL16481381;AKOS024335713;SB83240;Benzenamine, N-phenyl-3,5-bis(trifluoromethyl)-;3,5-Xylidine, .alpha.,.alpha.,.alpha.,.alpha.',.alpha.',.alpha.'-hexafluoro-N-phenyl-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-phenyl-3,5-bis(trifluoromethyl)aniline

Chemical Property:

XLogP3:5.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:305.06391826
Heavy Atom Count:21
Complexity:309

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F

Technology Process of N-phenyl-3,5-bis(trifluoromethyl)aniline

There total 8 articles about N-phenyl-3,5-bis(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 108-86-1,52753-63-6
bromobenzene

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 23917-96-6
N-phenyl-3,5-bis(trifluoromethyl)benzenamine

Guidance literature:: With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; sodium t-butanolate; In neat (no solvent); at 110 ℃; for 12h; Inert atmosphere; Green chemistry;
DOI:10.1002/ejoc.201501616

Reference yield: 88.0%

: 328-70-1
3,6-bis(trifluoromethyl)bromobenzene

: 62-53-3
aniline

: 23917-96-6
N-phenyl-3,5-bis(trifluoromethyl)benzenamine

Guidance literature:: With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In toluene; at 130 ℃; Inert atmosphere;
DOI:10.1021/jacs.8b08052

Reference yield: 88.0%

: 62-53-3
aniline

: 73852-19-4
3,5-bis-trifluromethylphenylboronic acid

: 23917-96-6
N-phenyl-3,5-bis(trifluoromethyl)benzenamine

Guidance literature:: With potassium hexafluorophosphate; ferrocenium hexafluorophosphate; copper(II) acetate dihydrate; sodium acetate; triethylamine; In acetonitrile; at 60 ℃; Inert atmosphere; Electrochemical reaction;
DOI:10.1021/jacs.1c02103