(R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

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Chemical Name:(R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate
CAS No.:1497422-17-9
Molecular Formula:C₅₈H₇₆N₈O₁₁S
Molecular Weight:1093.35
Hs Code.:

(R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Synonyms:(R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

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Chemical Property of (R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

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Technology Process of (R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

There total 7 articles about (R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1421596-08-8
2-[3-{(2-methylthiazol-4-yl)ethynyl}phenoxy]ethanamine

: 1497422-16-8
C₄₄H₆₄N₆O₁₁

: 1497422-17-9
(R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Guidance literature:: 2-[3-{(2-methylthiazol-4-yl)ethynyl}phenoxy]ethanamine; C₄₄H₆₄N₆O₁₁; With 4-methyl-morpholine; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 0.25h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/cn400175m

Reference yield:

: 873201-11-7
(2S)-2-bromopentanedioic acid 1-(1,1-dimethylethyl)-5-(phenylmethyl) ester

: 1497422-17-9
(R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / acetonitrile / 60 °C

2.1: base / acetonitrile / 80 °C

3.1: sodium hydroxide / water; methanol / 20 °C

4.1: benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C

4.2: 12 h / 20 °C

With 4-methyl-morpholine; sodium carbonate; benzotriazol-1-ol; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/cn400175m

Reference yield:

: 162148-48-3
(7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester

: 1497422-17-9
(R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / acetonitrile / 60 °C

2.1: base / acetonitrile / 80 °C

3.1: sodium hydroxide / water; methanol / 20 °C

4.1: benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C

4.2: 12 h / 20 °C

With 4-methyl-morpholine; sodium carbonate; benzotriazol-1-ol; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/cn400175m