methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

Base Information

Chemical Name:methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate
CAS No.:530089-23-7
Molecular Formula:C₂₃H₁₈ClF₂N₃O₃
Molecular Weight:457.864
Hs Code.:

Synonyms:methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

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Chemical Property of methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

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Technology Process of methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

There total 2 articles about methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 183171-54-2
methyl (2Z)-(4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

: 313674-12-3
2-chloro-4-(1H-pyrazol-1-yl)benzoic acid

: 530089-23-7
methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

Guidance literature:: 2-chloro-4-(1H-pyrazol-1-yl)benzoic acid; With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1h;

methyl (2Z)-(4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate; With pyridine; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2008.09.039

Reference yield:

: 530089-23-7
methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

Guidance literature:

Reference yield:

: 530089-23-7
methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

: 1092770-29-0
C₂₂H₁₆ClF₂N₃O₃

Guidance literature:: methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; methanol; chloroform; water;
DOI:10.1016/j.bmc.2008.09.039