(3S)-3-(tert-butyldimethylsilanyloxy)-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde

Base Information

Chemical Name:(3S)-3-(tert-butyldimethylsilanyloxy)-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde
CAS No.:494803-11-1
Molecular Formula:C₁₇H₂₈N₂O₅Si
Molecular Weight:368.505
Hs Code.:

Synonyms:(3S)-3-(tert-butyldimethylsilanyloxy)-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde

Suppliers and Price of (3S)-3-(tert-butyldimethylsilanyloxy)-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-3-(tert-butyldimethylsilanyloxy)-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde

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Technology Process of (3S)-3-(tert-butyldimethylsilanyloxy)-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde

There total 3 articles about (3S)-3-(tert-butyldimethylsilanyloxy)-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 494803-09-7
(3S)-3-hydroxy-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde

: 494803-11-1
(3S)-3-(tert-butyldimethylsilanyloxy)-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0957-4166(02)00410-X

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 494803-11-1
(3S)-3-(tert-butyldimethylsilanyloxy)-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-n-butylboron triflate; Et₃N / CH₂Cl₂ / -78 - 0 °C

1.2: CH₂Cl₂ / -78 - 20 °C

2.1: AlMe₃ / tetrahydrofuran; toluene / 0 - 20 °C

2.2: 78 percent / tetrahydrofuran; toluene / 4 h / 0 °C

3.1: 100 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0957-4166(02)00410-X

Reference yield:

: 494803-05-3
(3'S,4S)-4-benzyl-3-[3'-hydroxy-3'-(4-nitrophenyl)propionyl]oxazolidin-2-one

: 494803-11-1
(3S)-3-(tert-butyldimethylsilanyloxy)-N-methoxy-N-methyl-3-(4-nitrophenyl)propionamde

Guidance literature:: Multi-step reaction with 2 steps

1.1: AlMe₃ / tetrahydrofuran; toluene / 0 - 20 °C

1.2: 78 percent / tetrahydrofuran; toluene / 4 h / 0 °C

2.1: 100 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; trimethylaluminum; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0957-4166(02)00410-X