3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid potassium salt

Base Information

Chemical Name:3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid potassium salt
CAS No.:1035155-17-9
Molecular Formula:C₂₃H₂₈F₂NO₃*K
Molecular Weight:443.575
Hs Code.:

Synonyms:3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid potassium salt

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Chemical Property of 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid potassium salt

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Technology Process of 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid potassium salt

There total 19 articles about 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035154-04-1
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid

: 1035155-17-9
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid potassium salt

Guidance literature:: With potassium hydroxide; In water; acetone; at 0 - 5 ℃; Product distribution / selectivity;

Reference yield:

: 5-bromo-2,3-difluoro-phenol

: 1035155-17-9
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid potassium salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: propiononitrile / 0.25 h / 120 °C

1.2: 22 h / 20 °C

2.1: hydrogen / 5% palladium over charcoal / ethanol / 42.5 h / 2844.39 Torr

2.2: 0.5 h / 3102.97 Torr

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 22 h / 20 °C

4.2: 2 h / 20 °C

5.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

5.2: 5 h / 20 °C

6.1: pyridine / 4.62 h / -20 - -10 °C

7.1: potassium carbonate / ethanol / 96 h / 20 °C

8.1: ethanol / 36 h / 70 °C

9.1: sodium hydroxide; water / methanol / 15 h / 20 °C

10.1: potassium hydroxide / water; acetone / 0 - 5 °C

With pyridine; potassium hydroxide; sodium hydroxide; AD-mix-α; water; hydrogen; potassium carbonate; triethylamine; lithium chloride; bis(tributylphosphine) palladium; 5% palladium over charcoal; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; propiononitrile; tert-butyl alcohol; 4.1: Curtius Rearrangement;

Reference yield:

: 1035154-98-3
ethyl 3-(3,4-difluoro-5-hydroxyphenyl)propanoate

: 1035155-17-9
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid potassium salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 22 h / 20 °C

2.2: 2 h / 20 °C

3.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

3.2: 5 h / 20 °C

4.1: pyridine / 4.62 h / -20 - -10 °C

5.1: potassium carbonate / ethanol / 96 h / 20 °C

6.1: ethanol / 36 h / 70 °C

7.1: sodium hydroxide; water / methanol / 15 h / 20 °C

8.1: potassium hydroxide / water; acetone / 0 - 5 °C

With pyridine; potassium hydroxide; sodium hydroxide; AD-mix-α; water; potassium carbonate; triethylamine; lithium chloride; bis(tributylphosphine) palladium; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 2.1: Curtius Rearrangement;