3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid

Base Information

Chemical Name:3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid
CAS No.:1035154-04-1
Molecular Formula:C₂₃H₂₉F₂NO₃
Molecular Weight:405.485
Hs Code.:

Synonyms:3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid

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Chemical Property of 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid

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Technology Process of 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid

There total 17 articles about 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035154-02-9
ethyl 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoate

: 1035154-04-1
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid

Guidance literature:: With sodium hydroxide; water; In methanol; at 20 ℃; for 15h;

Reference yield:

: 5-bromo-2,3-difluoro-phenol

: 1035154-04-1
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tri-p-tolylphosphite / propiononitrile / 120 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 20 °C

3.2: 2 h

4.1: AD-mix-α / water; tert-butyl alcohol / 6 h / 0 - 20 °C

5.1: pyridine / -15 - 0 °C

6.1: potassium carbonate / ethanol / 96 h / 20 °C

7.1: ethanol / 36 h / 70 °C

8.1: sodium hydroxide; water / methanol / 15 h / 20 °C

With pyridine; sodium hydroxide; AD-mix-α; water; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium diacetate; bis(tributylphosphine) palladium; tri-p-tolylphosphite; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; propiononitrile; tert-butyl alcohol; 3.1: Stille Reaction;

Reference yield:

: 1035154-96-1
ethyl (2E)-3-(3,4-difluoro-5-hydroxyphenyl)-2-propenoate

: 1035154-04-1
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / 5% palladium over charcoal / ethanol / 42.5 h / 2844.39 Torr

1.2: 0.5 h / 3102.97 Torr

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 22 h / 20 °C

3.2: 2 h / 20 °C

4.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

4.2: 5 h / 20 °C

5.1: pyridine / 4.62 h / -20 - -10 °C

6.1: potassium carbonate / ethanol / 96 h / 20 °C

7.1: ethanol / 36 h / 70 °C

8.1: sodium hydroxide; water / methanol / 15 h / 20 °C

With pyridine; sodium hydroxide; AD-mix-α; water; hydrogen; potassium carbonate; triethylamine; lithium chloride; bis(tributylphosphine) palladium; 5% palladium over charcoal; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: Curtius Rearrangement;