tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1307255-03-3
Molecular Formula:C₂₀H₂₈FNO₄
Molecular Weight:365.445
Hs Code.:

Synonyms:tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

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Technology Process of tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 6 articles about tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307255-01-1
C₁₉H₂₆FNO₄

: 74-88-4
methyl iodide

: 1307255-03-3
tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; Cooling with ice;

Reference yield:

: 51446-30-1
2-fluoro-5-hydroxybenzoic acid

: 1307255-03-3
tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 80 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Cooling with ice

3.2: 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / Cooling with ice

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; sulfuric acid; sodium hydride; triphenylphosphine; In tetrahydrofuran; toluene; mineral oil;

Reference yield:

: 185099-67-6
N-Boc-nortropinone

: 1307255-03-3
tert-Butyl (3-endo)-3-[4-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: calcium chloride / methanol / 0.5 h / Cooling with ice

1.2: 1 h

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Cooling with ice

3.2: 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / Cooling with ice

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; calcium chloride; In tetrahydrofuran; methanol; toluene; mineral oil;