N-((1R,3S,5R)-3-Benzyloxy-5-chloro-cycloheptyl)-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-((1R,3S,5R)-3-Benzyloxy-5-chloro-cycloheptyl)-4-methyl-benzenesulfonamide
CAS No.:115522-53-7
Molecular Formula:C₂₁H₂₆ClNO₃S
Molecular Weight:407.961
Hs Code.:

Synonyms:N-((1R,3S,5R)-3-Benzyloxy-5-chloro-cycloheptyl)-4-methyl-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1R,3S,5R)-3-Benzyloxy-5-chloro-cycloheptyl)-4-methyl-benzenesulfonamide

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Technology Process of N-((1R,3S,5R)-3-Benzyloxy-5-chloro-cycloheptyl)-4-methyl-benzenesulfonamide

There total 5 articles about N-((1R,3S,5R)-3-Benzyloxy-5-chloro-cycloheptyl)-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 115522-51-5,115589-51-0
N-((1R,3S,5S)-3-Benzyloxy-5-hydroxy-cycloheptyl)-4-methyl-benzenesulfonamide

: 115522-53-7
N-((1R,3S,5R)-3-Benzyloxy-5-chloro-cycloheptyl)-4-methyl-benzenesulfonamide

Guidance literature:: With tributylphosphine; zinc(II) chloride; diethylazodicarboxylate; at 20 ℃; for 3h;
DOI:10.1016/S0040-4039(00)95578-3

Reference yield:

: 115522-58-2
6-(benzyloxy)-1,3-cycloheptadiene

: 115522-53-7
N-((1R,3S,5R)-3-Benzyloxy-5-chloro-cycloheptyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / LiCl, p-benzoquinone / Pd(OAc)2 (7percent) / acetic acid

2: 64 percent / Pd(PPh₃)4 (3percent) / acetonitrile; dimethylsulfoxide / 12 h / 20 °C

3: 95 percent / H₂ / RhCl(PPh₃)3 / ethanol / 15 h / 20 °C / 4560 Torr

4: 95 percent / NaOH / methanol; H₂O

5: 95 percent / EtO₂C-N=N-CO₂Et, ZnCl₂, PBu₃ / 3 h / 20 °C

With sodium hydroxide; tributylphosphine; hydrogen; p-benzoquinone; lithium chloride; zinc(II) chloride; diethylazodicarboxylate; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; RhCl(PPh₃)3; In methanol; ethanol; water; acetic acid; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0040-4039(00)95578-3

Reference yield:

: 115522-57-1,150338-86-6
1β-acetoxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene

: 115522-53-7
N-((1R,3S,5R)-3-Benzyloxy-5-chloro-cycloheptyl)-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / Pd(PPh₃)4 (3percent) / acetonitrile; dimethylsulfoxide / 12 h / 20 °C

2: 95 percent / H₂ / RhCl(PPh₃)3 / ethanol / 15 h / 20 °C / 4560 Torr

3: 95 percent / NaOH / methanol; H₂O

4: 95 percent / EtO₂C-N=N-CO₂Et, ZnCl₂, PBu₃ / 3 h / 20 °C

With sodium hydroxide; tributylphosphine; hydrogen; zinc(II) chloride; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; RhCl(PPh₃)3; In methanol; ethanol; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0040-4039(00)95578-3