Benzoic acid (3R,4R)-3-methanesulfonyloxy-1-(toluene-4-sulfonyl)-azepan-4-yl ester

Base Information

Chemical Name:Benzoic acid (3R,4R)-3-methanesulfonyloxy-1-(toluene-4-sulfonyl)-azepan-4-yl ester
CAS No.:200340-31-4
Molecular Formula:C₂₁H₂₅NO₇S₂
Molecular Weight:467.564
Hs Code.:

Synonyms:Benzoic acid (3R,4R)-3-methanesulfonyloxy-1-(toluene-4-sulfonyl)-azepan-4-yl ester

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Chemical Property of Benzoic acid (3R,4R)-3-methanesulfonyloxy-1-(toluene-4-sulfonyl)-azepan-4-yl ester

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Technology Process of Benzoic acid (3R,4R)-3-methanesulfonyloxy-1-(toluene-4-sulfonyl)-azepan-4-yl ester

There total 7 articles about Benzoic acid (3R,4R)-3-methanesulfonyloxy-1-(toluene-4-sulfonyl)-azepan-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 124-63-0
methanesulfonyl chloride

: 200340-27-8
(3R,4R)-N-p-toluenesulfonyl-4-benzoyloxy-3-hydroxy-hexahydroazepine

: 200340-31-4
Benzoic acid (3R,4R)-3-methanesulfonyloxy-1-(toluene-4-sulfonyl)-azepan-4-yl ester

Guidance literature:: With triethylamine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(97)10139-9

Reference yield:

: 1863-63-4
ammonium benzoate

: 200340-31-4
Benzoic acid (3R,4R)-3-methanesulfonyloxy-1-(toluene-4-sulfonyl)-azepan-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 24 h / 80 °C

2: conc. H₂SO₄, H₂O / 2 h / Heating

3: 97 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With sulfuric acid; water; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)10139-9

Reference yield:

: 200339-89-5
(5S,6R)-5,6-O-isopropylidene-azepane-2-one

: 200340-31-4
Benzoic acid (3R,4R)-3-methanesulfonyloxy-1-(toluene-4-sulfonyl)-azepan-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LiAlH₄ / 1.) THF, room temperature, 2 h, 2.) Py, -20 deg C, 1 h

2: 90 percent / 5percent HCl / methanol / 1 h / Ambient temperature

3: 1.) SOCl₂, Et₃N, 2.) NaIO₄, RuCl₃ / 1.) CH₂Cl₂, room temperature, 15 min, 2.) CCl₄, CH₃CN, H₂O, 0 deg C, 1 h

4: dimethylformamide / 24 h / 80 °C

5: conc. H₂SO₄, H₂O / 2 h / Heating

6: 97 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; water; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)10139-9