Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester

Base Information

• Chemical Name: Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester
• CAS No.: 1076089-07-0
• Molecular Formula: C₂₆H₃₆N₄O₅S
• Molecular Weight: 516.662
• Mol file: 1076089-07-0.mol

Synonyms:Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester

Chemical Property of Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester

There total 3 articles about Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester (813452-49-2) → Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester (1076089-07-0)

Guidance literature:

With piperidine; In dichloromethane; at 20 ℃; for 13.5h;

DOI:10.1021/cc1000105

Reference yield:

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester (1076089-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

2: piperidine / tetrahydrofuran / 0.5 h / 20 °C

With piperidine; dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo4007893

Reference yield:

benzyl bromide (100-39-0) → Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester (1076089-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

2: piperidine / tetrahydrofuran / 0.5 h / 20 °C

With piperidine; dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo4007893

upstream raw materials:

Nα-Fmoc-N(G)-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine benzyl ester

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

benzyl bromide

Downstream raw materials:

C₆₂H₇₂N₁₂O₁₄S₂

C₄₀H₅₂N₆O₇S

C₅₆H₇₁N₇O₁₂S

C₄₁H₅₉N₇O₁₀S