ethyl (E)-3-[5-(adamant-1-yl)-2-(3-(tert-butoxycarbonylamino)propoxy)-4-hydroxy-2-methylbiphenyl-4-yl]acrylate

Base Information

Chemical Name:ethyl (E)-3-[5-(adamant-1-yl)-2-(3-(tert-butoxycarbonylamino)propoxy)-4-hydroxy-2-methylbiphenyl-4-yl]acrylate
CAS No.:736992-51-1
Molecular Formula:C₃₅H₄₅NO₆
Molecular Weight:575.745
Hs Code.:

Synonyms:ethyl (E)-3-[5-(adamant-1-yl)-2-(3-(tert-butoxycarbonylamino)propoxy)-4-hydroxy-2-methylbiphenyl-4-yl]acrylate

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Chemical Property of ethyl (E)-3-[5-(adamant-1-yl)-2-(3-(tert-butoxycarbonylamino)propoxy)-4-hydroxy-2-methylbiphenyl-4-yl]acrylate

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Technology Process of ethyl (E)-3-[5-(adamant-1-yl)-2-(3-(tert-butoxycarbonylamino)propoxy)-4-hydroxy-2-methylbiphenyl-4-yl]acrylate

There total 14 articles about ethyl (E)-3-[5-(adamant-1-yl)-2-(3-(tert-butoxycarbonylamino)propoxy)-4-hydroxy-2-methylbiphenyl-4-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1566621-64-4
C₄₂H₆₁NO₆Si

: 736992-51-1
ethyl (E)-3-[5-(adamant-1-yl)-2-(3-(tert-butoxycarbonylamino)propoxy)-4-hydroxy-2-methylbiphenyl-4-yl]acrylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 2.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.01.006

Reference yield:

: 540779-38-2
ethyl (E)-4-bromo-3-hydroxycinnamate

: 736992-51-1
ethyl (E)-3-[5-(adamant-1-yl)-2-(3-(tert-butoxycarbonylamino)propoxy)-4-hydroxy-2-methylbiphenyl-4-yl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / K₂CO₃ / acetone / 20 h / Heating

2: 83 percent / Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 20 h / Heating

3: BBr₃ / CH₂Cl₂ / 2 h / -78 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; sodium carbonate; potassium carbonate; In 1,2-dimethoxyethane; dichloromethane; acetone;
DOI:10.1021/jm030524k

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 736992-51-1
ethyl (E)-3-[5-(adamant-1-yl)-2-(3-(tert-butoxycarbonylamino)propoxy)-4-hydroxy-2-methylbiphenyl-4-yl]acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 81 percent / K₂CO₃ / acetone / 20 h / Heating

3: 83 percent / Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 20 h / Heating

4: BBr₃ / CH₂Cl₂ / 2 h / -78 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; sodium carbonate; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; dichloromethane; acetone;
DOI:10.1021/jm030524k