ethyl 2-[1-phenyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

Base Information

Chemical Name:ethyl 2-[1-phenyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate
CAS No.:853055-03-5
Molecular Formula:C₂₂H₂₁NO₅S
Molecular Weight:411.478
Hs Code.:

Synonyms:ethyl 2-[1-phenyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

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Chemical Property of ethyl 2-[1-phenyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

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Technology Process of ethyl 2-[1-phenyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

There total 3 articles about ethyl 2-[1-phenyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 4755-77-5
Ethyl oxalyl chloride

: 189500-94-5
2-methyl-5-[4-(methylsulfonyl)phenyl]-1-phenyl-1H-pyrrole

: 853055-03-5
ethyl 2-[1-phenyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/jm049121q

Reference yield:

: 189501-33-5
1-[4-(methylthio)phenyl]pentane-1,4-dione

: 853055-03-5
ethyl 2-[1-phenyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / aq. Oxone(R) / methanol / 2 h / 25 °C

2: 80 percent / p-toluenesulfonic acid / toluene / 20 h / Heating

3: 76 percent / pyridine / CH₂Cl₂ / 4 h / 0 °C

With pyridine; oxone; toluene-4-sulfonic acid; In methanol; dichloromethane; toluene; 2: Paal-Knorr condensation;
DOI:10.1021/jm049121q

Reference yield:

: 189501-34-6
1-[4-(methylsulfonyl)phenyl]pentane-1,4-dione

: 853055-03-5
ethyl 2-[1-phenyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / p-toluenesulfonic acid / toluene / 20 h / Heating

2: 76 percent / pyridine / CH₂Cl₂ / 4 h / 0 °C

With pyridine; toluene-4-sulfonic acid; In dichloromethane; toluene; 1: Paal-Knorr condensation;
DOI:10.1021/jm049121q