ethyl 2-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

Base Information

Chemical Name:ethyl 2-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate
CAS No.:1355026-90-2
Molecular Formula:C₂₂H₂₆N₂O₄S₂
Molecular Weight:446.591
Hs Code.:

Synonyms:ethyl 2-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

Suppliers and Price of ethyl 2-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

There total 4 articles about ethyl 2-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355026-88-8
C₂₂H₂₄N₂O₄S₂

: 1355026-90-2
ethyl 2-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

Guidance literature:: With borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at 20 ℃; for 0.416667h; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.bmc.2012.02.018

Reference yield:

: 100367-77-9
ethyl 2-bromothiazole-4-carboxylate

: 1355026-90-2
ethyl 2-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / ethanol / 16 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0.33 h / 0 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

4.2: 1 h / 0 - 20 °C

5.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 0.42 h / 20 °C / Inert atmosphere

With borane-THF; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; ethanol; ethyl acetate; toluene; mineral oil; 4.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.bmc.2012.02.018

Reference yield:

: 1355026-69-5
ethyl 2-({2-[(2R)-2-formyl-5-oxo-1-pyrrolidinyl]ethyl}thio)-1,3-thiazole-4-carboxylate

: 1355026-90-2
ethyl 2-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxo-1-pyrrolidinyl}ethyl)thio]-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C

2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 0.42 h / 20 °C / Inert atmosphere

With borane-THF; sodium hydride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; mineral oil; 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.bmc.2012.02.018