1H-Imidazole-2-acetonitrile,alpha-hydroxy-1-methyl-,(alphaS)-(9CI)

Base Information

• Chemical Name: 1H-Imidazole-2-acetonitrile,alpha-hydroxy-1-methyl-,(alphaS)-(9CI)
• CAS No.: 290374-51-5
• Molecular Formula: C₆H₇N₃O
• Molecular Weight: 137.141
• Mol file: 290374-51-5.mol

Synonyms:1H-Imidazole-2-acetonitrile,alpha-hydroxy-1-methyl-,(alphaS)-(9CI)

Chemical Property of 1H-Imidazole-2-acetonitrile,alpha-hydroxy-1-methyl-,(alphaS)-(9CI)

Chemical Property:

Purity/Quality:

(aS)-a-hydroxy-1-methyl-1H-Imidazole-2-acetonitrile 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1H-Imidazole-2-acetonitrile,alpha-hydroxy-1-methyl-,(alphaS)-(9CI)

There total 3 articles about 1H-Imidazole-2-acetonitrile,alpha-hydroxy-1-methyl-,(alphaS)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium cyanide (151-50-8) + N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → 2-hydroxy-2-(1-methyl-2-imidazolyl)acetonitrile (290374-51-5)

Guidance literature:

N-methyl-2-imidazolcarboxaldehyde; With sodium hydrogensulfite; In diethyl ether; at 0 ℃; for 1h;

potassium cyanide; In diethyl ether; water; at 0 - 30 ℃;

DOI:10.1016/S0957-4166(02)00005-8

Reference yield:

trimethylsilyl cyanide (7677-24-9) + N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → 2-hydroxy-2-(1-methyl-2-imidazolyl)acetonitrile (290374-51-5)

Guidance literature:

With zinc(II) iodide; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.7b01861

Reference yield:

2-hydroxy-2-methylpropanenitrile (75-86-5) + N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → 2-hydroxy-2-(1-methyl-2-imidazolyl)acetonitrile (290374-51-5)

Guidance literature:

DOI:10.1016/S0040-4039(01)91411-X

upstream raw materials:

2-hydroxy-2-methylpropanenitrile

N-methyl-2-imidazolcarboxaldehyde

potassium cyanide

trimethylsilyl cyanide

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