1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-<1''-<((tert-butyldimethylsilyl)oxy)methyl>-3''-(hydroxypropyl)>-2,5-piperazinedione

Base Information

Chemical Name:1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-<1''-<((tert-butyldimethylsilyl)oxy)methyl>-3''-(hydroxypropyl)>-2,5-piperazinedione
CAS No.:95694-63-6
Molecular Formula:C₃₅H₄₇N₃O₆SSi
Molecular Weight:665.926
Hs Code.:

Synonyms:1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-<1''-<((tert-butyldimethylsilyl)oxy)methyl>-3''-(hydroxypropyl)>-2,5-piperazinedione

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Chemical Property of 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-<1''-<((tert-butyldimethylsilyl)oxy)methyl>-3''-(hydroxypropyl)>-2,5-piperazinedione

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Technology Process of 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-<1''-<((tert-butyldimethylsilyl)oxy)methyl>-3''-(hydroxypropyl)>-2,5-piperazinedione

There total 2 articles about 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-<1''-<((tert-butyldimethylsilyl)oxy)methyl>-3''-(hydroxypropyl)>-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.2%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 95782-44-8
syn-1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-<1''-(hydroxymethyl)-3''-(hydroxypropyl)>-2,5-piperazinedione (minor diastereomer)

: 95694-63-6
1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-<1''-<((tert-butyldimethylsilyl)oxy)methyl>-3''-(hydroxypropyl)>-2,5-piperazinedione

: 95694-62-5
1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-<1''-(hydroxymethyl)-3''-<((tert-butyldimethylsilyl)oxy)propyl>>-2,5-piperazinedione

Guidance literature:: With triethylamine; In tetrahydrofuran; for 14h; Ambient temperature;
DOI:10.1021/ja00297a035

Reference yield:

: 92216-26-7
1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-γ-butyrolactonyl)-2,5-piperazinedione (syn, minor diastereomer)

: 95694-63-6
1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-<1''-<((tert-butyldimethylsilyl)oxy)methyl>-3''-(hydroxypropyl)>-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 19 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / 0 °C

2: 16.2 percent / Et₃N / tetrahydrofuran / 14 h / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja00297a035