Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

Base Information

Chemical Name:Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine
CAS No.:203795-82-8
Molecular Formula:C₄₁H₆₆N₁₀O₃
Molecular Weight:747.04
Hs Code.:

Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

Synonyms:Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

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Chemical Property of Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

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Technology Process of Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

There total 9 articles about Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 103-67-3
benzyl-methyl-amine

: 203795-76-0
Methanesulfonic acid (R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl ester

: 203795-82-8
Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

Guidance literature:: DOI:10.1021/ja973881r

Reference yield:

: 3758-71-2
3α,7α,12α-trihydroxycholan-24-ol

: 203795-82-8
Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / Et₃N / dimethylformamide

2: 96 percent / NaH / tetrahydrofuran

3: 1.) 9-BBN, 2.) H₂O₂, NaOH / 1.) THF

4: 99 percent / Et₃N / CH₂Cl₂

5: 95 percent / NaN₃ / dimethylsulfoxide

6: 95 percent / TsOH / methanol

7: 97 percent / Et₃N / CH₂Cl₂

8: 96 percent

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; sodium azide; dihydrogen peroxide; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja973881r

Reference yield:

: 1448-36-8
methyl cholate

: 203795-82-8
Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-azido-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / LiAlH₄ / tetrahydrofuran

2: 90 percent / Et₃N / dimethylformamide

3: 96 percent / NaH / tetrahydrofuran

4: 1.) 9-BBN, 2.) H₂O₂, NaOH / 1.) THF

5: 99 percent / Et₃N / CH₂Cl₂

6: 95 percent / NaN₃ / dimethylsulfoxide

7: 95 percent / TsOH / methanol

8: 97 percent / Et₃N / CH₂Cl₂

9: 96 percent

With sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; sodium azide; dihydrogen peroxide; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja973881r