C₁₃H₉BrClNO₅

Base Information

• Chemical Name: C₁₃H₉BrClNO₅
• CAS No.: 1447125-22-5
• Molecular Formula: C₁₃H₉BrClNO₅
• Molecular Weight: 374.575
• Mol file: 1447125-22-5.mol

Synonyms:C₁₃H₉BrClNO₅

Chemical Property of C₁₃H₉BrClNO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₉BrClNO₅

There total 1 articles about C₁₃H₉BrClNO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-6-chloro-isatoic anhydride (943138-45-2) + allyl bromoacetate (40630-84-0) → C13H9BrClNO5 (1447125-22-5)

Guidance literature:

5-bromo-6-chloro-isatoic anhydride; With sodium hydride; In N,N-dimethyl-formamide; paraffin oil; for 0.75h; Cooling with ice;

allyl bromoacetate; In N,N-dimethyl-formamide; paraffin oil; at 20 ℃; for 5h;

DOI:10.1021/ol401710a

Reference yield: 80.0%

C13H9BrClNO5 (1447125-22-5) + allyl alcohol (107-18-6) → C15H15BrClNO4 (1447125-25-8)

Guidance literature:

With sodium hydride; In paraffin oil; at 20 ℃; for 6.5h;

DOI:10.1021/ol401710a

Reference yield:

C13H9BrClNO5 (1447125-22-5) → 5-bromo-4-chloro-3-indolyl β-D-galactopyranoside (7240-90-6,1174456-59-7)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium hydride / 6.5 h / 20 °C / Inert atmosphere

2: potassium tert-butylate / diethyl ether / 2 h / 40 - 45 °C / Inert atmosphere

3: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / water; dichloromethane / 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; morpholine / tetrahydrofuran / 20 °C

5: potassium carbonate; silver(I) acetate / 0.33 h / 90 - 100 °C

6: sodium methylate / methanol / 20 °C

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; sodium methylate; silver(I) acetate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 2: |Dieckmann Condensation;

DOI:10.1002/ejoc.201301198

upstream raw materials:

5-bromo-6-chloro-isatoic anhydride

allyl bromoacetate

Downstream raw materials:

(5-Bromo-4-chloro-indol-3-yl)-β-L-fucopyranoside

5-bromo-4-chloro-indol-3-yl-(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosylonic acid)

C₁₅H₁₅BrClNO₄

5-bromo-4-chloro-3-indolyl β-D-galactopyranoside