tert-butyl 4-[2-(benzyloxy)-5-cyclopropyl-8-fluoro-1,2,3,5-tetrahydro-1,3-dioxopyrimido[1,6-a]benzimidazol-7-yl]-1-piperazinecarboxylate

Base Information

Chemical Name:tert-butyl 4-[2-(benzyloxy)-5-cyclopropyl-8-fluoro-1,2,3,5-tetrahydro-1,3-dioxopyrimido[1,6-a]benzimidazol-7-yl]-1-piperazinecarboxylate
CAS No.:137858-31-2
Molecular Formula:C₂₉H₃₂FN₅O₅
Molecular Weight:549.602
Hs Code.:

Synonyms:tert-butyl 4-[2-(benzyloxy)-5-cyclopropyl-8-fluoro-1,2,3,5-tetrahydro-1,3-dioxopyrimido[1,6-a]benzimidazol-7-yl]-1-piperazinecarboxylate

Suppliers and Price of tert-butyl 4-[2-(benzyloxy)-5-cyclopropyl-8-fluoro-1,2,3,5-tetrahydro-1,3-dioxopyrimido[1,6-a]benzimidazol-7-yl]-1-piperazinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 4-[2-(benzyloxy)-5-cyclopropyl-8-fluoro-1,2,3,5-tetrahydro-1,3-dioxopyrimido[1,6-a]benzimidazol-7-yl]-1-piperazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 4-[2-(benzyloxy)-5-cyclopropyl-8-fluoro-1,2,3,5-tetrahydro-1,3-dioxopyrimido[1,6-a]benzimidazol-7-yl]-1-piperazinecarboxylate

There total 9 articles about tert-butyl 4-[2-(benzyloxy)-5-cyclopropyl-8-fluoro-1,2,3,5-tetrahydro-1,3-dioxopyrimido[1,6-a]benzimidazol-7-yl]-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 137858-30-1
tert-butyl 4-<2-<<(benzyloxycarbonyl)carbamoyl>methyl>-1-cyclopropyl-5-fluoro-6-benzimidazolyl>-1-piperazinecarboxylate

: 530-62-1
1,1'-carbonyldiimidazole

: 137858-31-2
tert-butyl 4-[2-(benzyloxy)-5-cyclopropyl-8-fluoro-1,2,3,5-tetrahydro-1,3-dioxopyrimido[1,6-a]benzimidazol-7-yl]-1-piperazinecarboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 60 ℃; for 2h;
DOI:10.1021/jm00086a006

Reference yield:

: 6674-22-2,83329-50-4
1,8-diazabicyclo[5.4.0]undec-7-ene

: 137858-30-1
tert-butyl 4-<2-<<(benzyloxycarbonyl)carbamoyl>methyl>-1-cyclopropyl-5-fluoro-6-benzimidazolyl>-1-piperazinecarboxylate

: 137858-31-2
tert-butyl 4-[2-(benzyloxy)-5-cyclopropyl-8-fluoro-1,2,3,5-tetrahydro-1,3-dioxopyrimido[1,6-a]benzimidazol-7-yl]-1-piperazinecarboxylate

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; water;

Reference yield:

: 578-28-9
1-Chloro-2,5-difluoro-4-nitrobenzene

: 137858-31-2
tert-butyl 4-[2-(benzyloxy)-5-cyclopropyl-8-fluoro-1,2,3,5-tetrahydro-1,3-dioxopyrimido[1,6-a]benzimidazol-7-yl]-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / triethylamine / Ambient temperature

2: 93 percent / triethylamine / 60 °C

3: 85 percent / KOH / methanol; H₂O / 3 h / 80 °C

4: 0.86 percent / NaHCO₃ / CHCl₃; H₂O / 2 h / Ambient temperature

5: 93 percent / H₂ / 5percent Pd/C / methanol

6: 15.5 percent / dimethylformamide / 1.5 h / 50 °C

7: 317 mg / H₂O; ethanol / 72 h / 50 °C

8: 61 percent / DBU / tetrahydrofuran / 2 h / 60 °C

With potassium hydroxide; hydrogen; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00086a006