578-28-9

Usage

Uses

Used in Industrial Processes:
4-Chloro-2,5-difluoronitrobenzene is used as a chemical intermediate for the synthesis of various compounds in the chemical industry. Its unique structure and reactivity make it a valuable component in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Laboratory Research:
In the field of scientific research, 4-Chloro-2,5-difluoronitrobenzene is employed as a reagent in various chemical reactions. It is particularly useful in the synthesis of complex organic molecules and the study of reaction mechanisms. Researchers utilize its properties to explore new pathways and develop innovative methodologies in organic chemistry.
Used in Environmental Monitoring:
4-Chloro-2,5-difluoronitrobenzene is also used as a reference compound in environmental monitoring and analysis. Its distinct chemical signature allows for the detection and quantification of related compounds in environmental samples, contributing to the assessment of pollution levels and the development of remediation strategies.

InChI:InChI=1/C6H2ClF2NO2/c7-3-1-5(9)6(10(11)12)2-4(3)8/h1-2H

Upstream product

• 1542-36-5 2,5-difluoro-4-nitroaniline 
• 540-36-3 para-difluorobenzene 
• 2367-91-1 1-chloro-2,5-difluorobenzene 

Downstream Products

• 2105-61-5 1,2,4-trifluoro-5-nitrobenzene 
• 135861-04-0 5-chloro-n-cyclopropyl-4-fluoro-2-nitroaniline 
• 413597-24-7 5-chloro-4-fluoro-2-nitro-N-propylaniline 
• 2613-30-1 4-chloro-2,5-difluoroaniline 
• 932374-35-1 1,1-dimethylethyl 4-[(5-chloro-4-fluoro-2-nitrophenyl)amino]piperidinecarboxylate 
• 224168-12-1 ethyl (4-chloro-3,6-difluoro-2-nitrophenyl)carbamate 

Relevant academic research and scientific papers

Di- and Trifluorinated 2-Azidobenzimidazole Derivatives: Synthesis, Photooxygenation, and 19F NMR Prediction

The photoreactivity of a series of hitherto unknown, multiply fluorinated 2-azidobenzimidazole derivatives was investigated. The synthesis of the starting material includes regioselective p-defluorination of nitrobenzene derivatives employing Ogoshi's conditions. If the 6-position was unsubstituted, irradiation in the presence of N-protected amino acids at 300 nm (Rayonet) led to the formation of arylesters by oxygenation of the 6-position in good to excellent yields and perfect regioselectivity. We did not observe any displacement of fluoride. If the 6-position itself was fluorinated, alternative positions of the benzene portion were attacked. Mechanistically, the reaction proceeds through ring opening of the singlet nitrene to the cyanodiimine or via the iminobenzimidazolium ion. The availability of a set of fluorinated photo-adducts prompted the quantum chemical calculation of their 19F NMR chemical shifts. Even with the most suitable method investigated (ωB97XD/TApr-cc-pVDZ), deviations of up to 5 ppm from the experimental values were observed, underlining the importance of experimental measurements.

FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES

A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[l,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I) and salts and solvates are provided: In a first aspect therefore, the invention provides a compound of formula (I) or a salt or solvate thereof: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C 1-6 alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Substituted benzene compounds, process for their preparation, and herbicidal and defoliant compositions containing them

Novel herbicidal and defoliant substituted aniline derived compounds represented by general structure (I) are described. W, X, Y, Z, and Q are as defined in the disclosure. Also described are the processes for the manufacture of these compounds and agriculturally suitable compositions containing these as active ingredients which are useful as herbicides for general or selective pre-emergent or post-emergent control of undesired plant species and defoliants at very low concentrations of these biologically active compounds.

Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones

Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia, and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, and inducing anesthesia are disclosed by administering to an animal in need of such treatment an alkyl or azido-substituted 1,4-dihydroquinoxaline-2,3-dione or pharmaceutically acceptable salts thereof, which have high binding to the glycine receptor.

Procedure for the preparation of N-cyclopropyl-4-fluoroanilines

Procedure for the preparation of N-cyclopropyl-4-fluoroanilines of formula I. By selective reaction of II with cyclopropylamine, piperazines or pyrrolidines, III is obtained. Its acetylation and reduction yields IV which by de-amination leads to I. R1 is