4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

Base Information

Chemical Name:4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone
CAS No.:1428929-07-0
Molecular Formula:C₁₉H₁₆F₃NO₂
Molecular Weight:347.337
Hs Code.:

Synonyms:4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

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Chemical Property of 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

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Technology Process of 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

There total 7 articles about 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1428929-06-9
2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine

: 1428929-07-0
4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

Guidance literature:: With hydrogenchloride; In water; acetone; at 60 ℃;
DOI:10.1016/j.bmcl.2018.11.048

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 1428929-07-0
4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

3.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

4.1: 18 h / 150 °C

5.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 - 20 °C

5.2: 18 h / 0 - 20 °C

6.1: hydrogenchloride; water / acetone / 4 h / 60 °C

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; water; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil; 5.1: |Wittig-Horner Reaction / 5.2: |Wittig-Horner Reaction;

Reference yield:

: 1020325-22-7
[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methanol

: 1428929-07-0
4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

2.1: 18 h / 150 °C

3.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 - 20 °C

3.2: 18 h / 0 - 20 °C

4.1: hydrogenchloride; water / acetone / 4 h / 60 °C

With hydrogenchloride; thionyl chloride; water; sodium hydride; In tetrahydrofuran; dichloromethane; acetone; mineral oil; 3.1: |Wittig-Horner Reaction / 3.2: |Wittig-Horner Reaction;