4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

Base Information

• Chemical Name: 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone
• CAS No.: 1428929-07-0
• Molecular Formula: C₁₉H₁₆F₃NO₂
• Molecular Weight: 347.337
• Mol file: 1428929-07-0.mol

Synonyms:4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

Chemical Property of 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone

There total 7 articles about 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine (1428929-06-9) → 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone (1428929-07-0)

Guidance literature:

With hydrogenchloride; In water; acetone; at 60 ℃;

DOI:10.1016/j.bmcl.2018.11.048

Reference yield:

meta-hydroxybenzaldehyde (100-83-4) → 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone (1428929-07-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

3.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

4.1: 18 h / 150 °C

5.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 - 20 °C

5.2: 18 h / 0 - 20 °C

6.1: hydrogenchloride; water / acetone / 4 h / 60 °C

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; water; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil; 5.1: |Wittig-Horner Reaction / 5.2: |Wittig-Horner Reaction;

Reference yield:

[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methanol (1020325-22-7) → 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexanone (1428929-07-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

2.1: 18 h / 150 °C

3.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 - 20 °C

3.2: 18 h / 0 - 20 °C

4.1: hydrogenchloride; water / acetone / 4 h / 60 °C

With hydrogenchloride; thionyl chloride; water; sodium hydride; In tetrahydrofuran; dichloromethane; acetone; mineral oil; 3.1: |Wittig-Horner Reaction / 3.2: |Wittig-Horner Reaction;

upstream raw materials:

3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde

meta-hydroxybenzaldehyde

2-chloro-5-trifluoromethylpyridine

[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methanol

Downstream raw materials:

N-[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexyl]pyridine-3-carboxamide

6-methyl-N-[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]pyridine-3-carboxamide

4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine