2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine

Base Information

Chemical Name:2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine
CAS No.:1428929-06-9
Molecular Formula:C₂₁H₂₀F₃NO₃
Molecular Weight:391.39
Hs Code.:

Synonyms:2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine

Suppliers and Price of 2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine

There total 6 articles about 2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1020325-38-5
2-[3-(diethoxyphosphorylmethyl)phenoxy]-5-(trifluoromethyl)pyridine

: 1428929-06-9
2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine

Guidance literature:: 2-[3-(diethoxyphosphorylmethyl)phenoxy]-5-(trifluoromethyl)pyridine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 4h;

cyclohexanedione monoethylene ketal; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 18h;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 1428929-06-9
2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

3.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

4.1: 18 h / 150 °C

5.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 - 20 °C

5.2: 18 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 5.1: |Wittig-Horner Reaction / 5.2: |Wittig-Horner Reaction;

Reference yield:

: 1020325-22-7
[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methanol

: 1428929-06-9
2-[3-(1,4-dioxaspiro[4.5]decan-8-ylidenemethyl)phenoxy]-5-(trifluoromethyl) pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

2.1: 18 h / 150 °C

3.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 - 20 °C

3.2: 18 h / 0 - 20 °C

With thionyl chloride; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil; 3.1: |Wittig-Horner Reaction / 3.2: |Wittig-Horner Reaction;