3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester

Base Information

Chemical Name:3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester
CAS No.:251958-02-8
Molecular Formula:C₄₆H₈₀F₃NO₄Si₂
Molecular Weight:824.312
Hs Code.:

3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester

Synonyms:3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester

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Chemical Property of 3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester

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Technology Process of 3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester

There total 1 articles about 3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 3-Trifluoromethyl-benzoic acid (1S,7S)-1-((2R,5R,6S)-6-methyl-5-triisopropylsilanyloxy-piperidin-2-yl)-7-triisopropylsilanyloxy-tetradeca-4,5-dienyl ester

: 251958-02-8
3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester

Guidance literature:: With silver nitrate; In acetone;
DOI:10.1021/ja9925958

Reference yield:

: 251958-02-8
3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester

: 251958-22-2
Acetic acid (3R,4S,6S,9aS)-4-methyl-6-((E)-(S)-3-phenylsulfanyl-dec-1-enyl)-octahydro-quinolizin-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / DIBAL-H

3: 28 percent / LiAlH₄

4: pyridine

5: aq. HF

6: 74 percent / n-Bu₃P

With pyridine; lithium aluminium tetrahydride; tributylphosphine; hydrogen fluoride; diisobutylaluminium hydride; 1: Reduction / 2: mesylation / 3: Reduction / 4: Acetylation / 5: desilylation / 6: Substitution;
DOI:10.1021/ja9925958

Reference yield:

: 251958-02-8
3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester

: 251958-23-3
Acetic acid (3R,4S,6S,9aS)-6-((E)-(S)-3-benzenesulfinyl-dec-1-enyl)-4-methyl-octahydro-quinolizin-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / DIBAL-H

3: 28 percent / LiAlH₄

4: pyridine

5: aq. HF

6: 74 percent / n-Bu₃P

7: Oxone

With pyridine; Oxone; lithium aluminium tetrahydride; tributylphosphine; hydrogen fluoride; diisobutylaluminium hydride; 1: Reduction / 2: mesylation / 3: Reduction / 4: Acetylation / 5: desilylation / 6: Substitution / 7: Oxidation;
DOI:10.1021/ja9925958