Acetic acid (3R,4S,6S,9aS)-6-((E)-(S)-3-benzenesulfinyl-dec-1-enyl)-4-methyl-octahydro-quinolizin-3-yl ester

Base Information

Chemical Name:Acetic acid (3R,4S,6S,9aS)-6-((E)-(S)-3-benzenesulfinyl-dec-1-enyl)-4-methyl-octahydro-quinolizin-3-yl ester
CAS No.:251958-23-3
Molecular Formula:C₂₈H₄₃NO₃S
Molecular Weight:473.72
Hs Code.:

Synonyms:Acetic acid (3R,4S,6S,9aS)-6-((E)-(S)-3-benzenesulfinyl-dec-1-enyl)-4-methyl-octahydro-quinolizin-3-yl ester

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Chemical Property of Acetic acid (3R,4S,6S,9aS)-6-((E)-(S)-3-benzenesulfinyl-dec-1-enyl)-4-methyl-octahydro-quinolizin-3-yl ester

Chemical Property:

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Technology Process of Acetic acid (3R,4S,6S,9aS)-6-((E)-(S)-3-benzenesulfinyl-dec-1-enyl)-4-methyl-octahydro-quinolizin-3-yl ester

There total 12 articles about Acetic acid (3R,4S,6S,9aS)-6-((E)-(S)-3-benzenesulfinyl-dec-1-enyl)-4-methyl-octahydro-quinolizin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 251958-04-0
(1S,4S,6S,7R,9aR)-6-Methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-ol

: 251958-23-3
Acetic acid (3R,4S,6S,9aS)-6-((E)-(S)-3-benzenesulfinyl-dec-1-enyl)-4-methyl-octahydro-quinolizin-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

2: 28 percent / LiAlH₄

3: pyridine

4: aq. HF

5: 74 percent / n-Bu₃P

6: Oxone

With pyridine; Oxone; lithium aluminium tetrahydride; tributylphosphine; hydrogen fluoride; 1: mesylation / 2: Reduction / 3: Acetylation / 4: desilylation / 5: Substitution / 6: Oxidation;
DOI:10.1021/ja9925958

Reference yield:

: 251958-02-8
3-Trifluoromethyl-benzoic acid (1S,4S,6S,7R,9aR)-6-methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-octahydro-quinolizin-1-yl ester

: 251958-23-3
Acetic acid (3R,4S,6S,9aS)-6-((E)-(S)-3-benzenesulfinyl-dec-1-enyl)-4-methyl-octahydro-quinolizin-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / DIBAL-H

3: 28 percent / LiAlH₄

4: pyridine

5: aq. HF

6: 74 percent / n-Bu₃P

7: Oxone

With pyridine; Oxone; lithium aluminium tetrahydride; tributylphosphine; hydrogen fluoride; diisobutylaluminium hydride; 1: Reduction / 2: mesylation / 3: Reduction / 4: Acetylation / 5: desilylation / 6: Substitution / 7: Oxidation;
DOI:10.1021/ja9925958

Reference yield:

: (4S,6S,7R,9aR)-6-Methyl-7-triisopropylsilanyloxy-4-((E)-(S)-3-triisopropylsilanyloxy-dec-1-enyl)-hexahydro-quinolizin-1-one

: 251958-23-3
Acetic acid (3R,4S,6S,9aS)-6-((E)-(S)-3-benzenesulfinyl-dec-1-enyl)-4-methyl-octahydro-quinolizin-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NaBH₄ / methanol / 0 °C

3: 88 percent / LiAlH₄

4: pyridine

5: aq. HF

6: 74 percent / n-Bu₃P

7: Oxone

With pyridine; Oxone; sodium tetrahydroborate; lithium aluminium tetrahydride; tributylphosphine; hydrogen fluoride; In methanol; 1: Reduction / 2: mesylation / 3: Reduction / 4: Acetylation / 5: desilylation / 6: Substitution / 7: Oxidation;
DOI:10.1021/ja9925958