t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate

Base Information

Chemical Name:t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate
CAS No.:1242846-56-5
Molecular Formula:C₂₆H₂₅FN₂O₅S
Molecular Weight:496.559
Hs Code.:

Synonyms:t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate

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Chemical Property of t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate

Chemical Property:

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Technology Process of t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate

There total 5 articles about t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1242846-55-4
t-butyl 2-(2-bromo-4-((4-fluorophenylsulfonamido)rnethyl)phenoxy)acetate

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 1242846-56-5
t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 140 ℃; for 1h; Microwave irradiation;

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1242846-56-5
t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: ammonium acetate; acetic acid / methanol / 4 h / 20 °C

2.2: 18 h / 20 °C

3.1: triethylamine / dichloromethane / 4 h / 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 140 °C / microwave

With ammonium acetate; sodium carbonate; caesium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 1242846-56-5
t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: ammonium acetate; acetic acid / methanol / 4 h / 20 °C

2.2: 18 h / 20 °C

3.1: triethylamine / dichloromethane / 4 h / 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 140 °C / microwave

With ammonium acetate; sodium carbonate; caesium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;