Technology Process of (4R)-4-(2-amino-4-cyanophenyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
There total 7 articles about (4R)-4-(2-amino-4-cyanophenyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
at 20 ℃;
for 2h;
under 1 Torr;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethyl phosphate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere; Reflux
2: morpholine / tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
3: poly(N-methacryloyl-L-leucine-tert-butylamide) / ethyl acetate; methanol / Resolution of racemate
4: N-ethyl-N,N-diisopropylamine; ammonia; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dmap / tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere
5: Burgess Reagent / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
6: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 1 Torr / Inert atmosphere
With
morpholine; Burgess Reagent; triethyl phosphate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; hydrogen; N-ethyl-N,N-diisopropylamine;
dmap; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethyl phosphate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere; Reflux
2: morpholine / tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
3: poly(N-methacryloyl-L-leucine-tert-butylamide) / ethyl acetate; methanol / Resolution of racemate
4: N-ethyl-N,N-diisopropylamine; ammonia; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dmap / tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere
5: Burgess Reagent / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
6: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 1 Torr / Inert atmosphere
With
morpholine; Burgess Reagent; triethyl phosphate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; hydrogen; N-ethyl-N,N-diisopropylamine;
dmap; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate;
![(4R)-4-(4-Cyano-2-nitrophenyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile](/Databaselist/images/loading.webp)
