90178-78-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Formyl-3-nitrobenzonitrile is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs due to its reactive functional groups and structural diversity.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Formyl-3-nitrobenzonitrile is utilized as a starting material for the production of agrochemicals, playing a crucial role in the creation of effective compounds for crop protection and enhancement.
Used in Dye and Pigment Production:
4-Formyl-3-nitrobenzonitrile is employed as a reactant in the synthesis of dyes and pigments, where its chemical properties allow for the creation of a wide range of colorants used in various industries.
Used in Organic Synthesis:
As a building block in organic synthesis, 4-Formyl-3-nitrobenzonitrile is used for the preparation of heterocyclic compounds, which are essential components in many organic and medicinal chemistry applications.
Used in Drug Research and Development:
4-Formyl-3-nitrobenzonitrile is being studied for its potential biological activities, with ongoing research exploring its use as a drug candidate, indicating its potential in future therapeutic applications.

Upstream product

• 61293-30-9 trans-4-[β-(dimethylamino)vinyl]-3-nitrobenzonitrile 
• 90178-80-6 4-(chloromethyl)-3-nitrobenzonitrile 
• 90179-04-7 1-(4-Cyan-2-nitrobenzyl)pyridiniumchlorid 
• 104-85-8 para-methylbenzonitrile 
• 75-09-2 dichloromethane 
• 619-24-9 3-nitrobenzonitrile 
• 61293-30-9 4-((E)-2-Dimethylamino-vinyl)-3-nitro-benzonitrile 
• 939-79-7 4-cyano-2-nitrotoluene 
• 90178-79-3 C₁₆H₁₄N₄O₃ 

Downstream Products

• 104291-68-1 4,4'-(1,3,5-Hexatrien-1,6-diyl)bis-(3-nitrobenzonitril) 
• 90178-62-4 (E)-1-(4-cyano-2-nitrophenyl)-2-(4-(4-cyanophenoxy)phenyl)ethene 
• 104291-53-4 4-(2-Formylvinyl)-3-nitrobenzonitril 
• 104291-55-6 4-(4-Formyl-1,3-butadienyl)-3-nitrobenzonitril 
• 914106-37-9 4-cyano-2-nitrobenzaldoxime 
• 942614-29-1 4-(1H-benzimidazol-2-yl)-3-nitrobenzonitrile 
• 104291-56-7 4-(3-Hydroxy-1-propenyl)-3-nitrobenzonitril 
• 104291-58-9 4-(3-Brom-1-propenyl)-3-nitrobenzonitril 
• 55368-13-3 2-<4-(4-Cyanphenoxy)phenyl>indol-6-carbonitril 
• 104291-69-2 2-<4-(4-Cyan-2-nitrophenyl)-1,3-butadienyl>-6-indolcarbonitril 
• 55453-00-4 2-<4-(4-Amidinophenoxy)phenyl>indol-6-carboxamidin-dihydrochlorid 
• 90178-90-8 6-(2-Imidazolin-2-yl)-2-<4-<4-(2-imidazolin-2-yl)phenoxy>phenyl>indol-dihydrochlorid 
• 104291-60-3 <3-(4-Cyan-2-nitrophenyl)-2-propenyl>-triphenylphosphoniumbromid 
• 1214278-80-4 4-(2,2-dibromovinyl)-3-nitrobenzonitrile 

Relevant academic research and scientific papers

Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures

We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

Vicarious Nucleophilic Chloromethylation of Nitroaromatics

Nitroaromatics substituted with electron-acceptor or electron-donor groups undergo vicarious nucleophilic substitution with the lithium salt of dichloromethane to provide chloromethyl-substituted nitroaromatics in good to high yields. The methodology represents a new strategy for the synthesis of benzyl chlorides.

Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines

A novel series of extended DAPI analogues were prepared by insertion of either a carbon-carbon triple bond (16a-d) or a phenyl group (21a,b and 24) at position-2. The new amidines were evaluated in vitro against both Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.). Five compounds (16a, 16b, 16d, 21a, 21b) exhibited IC50 values against T. b. r. of 9 nM or less which is two to nine folds more effective than DAPI. The same five compounds exhibited IC50 values against P. f. of 5.9 nM or less which is comparable to that of DAPI. The fluorescence properties of these new molecules were recorded, however; they do not offer any advantage over those of DAPI.

Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles

3,5-Bis(4-amidinophenyl)isoxazole (3) - an analogue of 2,5-bis(4- amidinophenyl)furan (furamidine) in which the central furan ring is replaced by isoxazole - and 42 novel analogues were prepared by two general synthetic pathways. The 43 isoxazole derivati

Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles

Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.