{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol

Base Information

• Chemical Name: {4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol
• CAS No.: 934832-07-2
• Molecular Formula: C₂₂H₁₉FN₆O₂
• Molecular Weight: 418.43

Synonyms:{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol

Chemical Property of {4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol

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Technology Process of {4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol

There total 1 articles about {4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazine-5-carboxylic acid methyl ester → {4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol (934832-07-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2007.01.002

Reference yield: 75.0%

{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol (934832-07-2) + acetyl chloride (75-36-5) → acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester (934832-08-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmcl.2007.01.002

Reference yield:

{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol (934832-07-2) → [1-(3-fluoro-benzyl)-1H-indazol-5-yl]-[6-methoxy-5-(morpholin-2-ylmethoxymethyl)-pyrrolo[2,1-f][1,2,4]triazin-4-yl]-amine

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / DIPEA / CH₂Cl₂ / 0 °C

2: 1,2-dichloro-ethane / 18 h / 85 °C

3: TFA / 1,2-dichloro-ethane

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2007.01.002

Downstream raw materials:

acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester

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