(2R,3S,4S,5R)-2-(6-Amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-ol

Base Information

Chemical Name:(2R,3S,4S,5R)-2-(6-Amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-ol
CAS No.:82854-30-6
Molecular Formula:C₃₇H₄₅N₅O₆Si
Molecular Weight:683.88
Hs Code.:

Synonyms:(2R,3S,4S,5R)-2-(6-Amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-ol

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Chemical Property of (2R,3S,4S,5R)-2-(6-Amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-ol

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Technology Process of (2R,3S,4S,5R)-2-(6-Amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-ol

There total 3 articles about (2R,3S,4S,5R)-2-(6-Amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 57018-82-3
1-(6-amino-purin-9-yl)-O⁵-(4,4'-dimethoxy-trityl)-β-D-1-deoxy-arabinofuranose

: 18162-48-6
tert-butyldimethylsilyl chloride

: 82854-30-6
(2R,3S,4S,5R)-2-(6-Amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-ol

: 82854-28-2
(2R,3R,4S,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-ol

Guidance literature:: With pyridine; silver nitrate; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(00)87243-3

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 82854-30-6
(2R,3S,4S,5R)-2-(6-Amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / pyridine / dimethylformamide / 1 h / -5 °C

2: 5 percent / pyridine / silver nitrate / tetrahydrofuran / 3 h

With pyridine; silver nitrate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 5536-17-4
arabinosyl adenine

: 82854-30-6
(2R,3S,4S,5R)-2-(6-Amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / pyridine / dimethylformamide / 1 h / -5 °C

2: 5 percent / pyridine / silver nitrate / tetrahydrofuran / 3 h

With pyridine; silver nitrate; In tetrahydrofuran; N,N-dimethyl-formamide;