UCM05

Base Information

Chemical Name:UCM05
CAS No.:1094451-90-7
Molecular Formula:C₂₄H₁₆O₁₀
Molecular Weight:464.385
Hs Code.:
Mol file:1094451-90-7.mol

Synonyms:3-(3,4,5-trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate

Suppliers and Price of UCM05

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
G 28UCM
5mg
$ 403.00

TRC
G28UCM
100mg
$ 1405.00

Tocris
G28UCM ≥98%(HPLC)
50
$ 883.00

Tocris
G28UCM ≥98%(HPLC)
10
$ 210.00

Cayman Chemical
UCM05 ≥95%
10mg
$ 175.00

Cayman Chemical
UCM05 ≥95%
5mg
$ 94.00

Cayman Chemical
UCM05 ≥95%
1mg
$ 25.00

ApexBio Technology
UCM05
10mg
$ 243.00

ApexBio Technology
UCM05
5mg
$ 62.00

AK Scientific
UCM05
100mg
$ 1835.00

Total 4 raw suppliers

Chemical Property of UCM05

Chemical Property:

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

G 28UCM ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses UCM05 is an inhibitor of fatty acid synthase that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 μM for SK-BR-3 cells). It does not alter carnitine palmitoyltransferase 1 activity or induce weight loss in mice. UCM05 can reduce cleavage of poly(ADP-ribose) polymerase, phosphorylation of HER2, Akt, and ERK1/2, and growth of established xenografts in vivo. UCM05 also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus, preventing bacterial division.[Cayman Chemical] G 28UCM is a fatty acid synthase inhibitor with anticancer activity, novel inhibitor of fatty acid synthase with anticancer activity.

Technology Process of UCM05

There total 6 articles about UCM05 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1084333-71-0
1,3-bis([3,4,5-tris(benzyloxy)benzoyl]oxy)naphthalene

: 1094451-90-7
3-(3,4,5-trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate

Guidance literature:: With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; dichloromethane; at 20 ℃; under 2585.81 Torr;
DOI:10.1021/jm2016045

Reference yield: 50.0%

: 1094451-90-7
3-(3,4,5-trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate

Guidance literature:

Reference yield:

: 132-86-5
1,3-dihydroxynaphthalene

: 1094451-90-7
3-(3,4,5-trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol; dichloromethane / 20 °C / 2585.81 Torr

With 10 wt% Pd(OH)2 on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm2016045