Technology Process of (R)-N-benzyl-3-phenylbutanamide
There total 10 articles about (R)-N-benzyl-3-phenylbutanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-β-methylcinnamaldehyde;
With
1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; BF4(1-)*C21H22N3O(1+); 1,1'-biphenyl-2,2'-diyl hydrogen phosphate;
In
toluene;
at 40 ℃;
for 14h;
Molecular sieve;
Sealed tube;
Inert atmosphere;
benzylamine;
In
toluene;
at 20 ℃;
for 10h;
Temperature;
Reagent/catalyst;
enantioselective reaction;
Catalytic behavior;
Molecular sieve;
Sealed tube;
Inert atmosphere;
DOI:10.1002/anie.201803556
- Guidance literature:
-
3-phenyl-2-butenal;
With
1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; BF4(1-)*C21H22N3O(1+); 1,1'-biphenyl-2,2'-diyl hydrogen phosphate;
In
toluene;
at 40 ℃;
for 14h;
Molecular sieve;
Sealed tube;
Inert atmosphere;
4-methoxy-benzylamine;
In
toluene;
at 20 ℃;
for 10h;
enantioselective reaction;
Molecular sieve;
Sealed tube;
Inert atmosphere;
DOI:10.1002/anie.201803556
- Guidance literature:
-
With
rac-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; potassium carbonate;
(acetylacetonato)(η2-ethene)rhodium(I);
In
1,4-dioxane; water;
at 100 ℃;
for 16h;
Title compound not separated from byproducts.;
DOI:10.1021/jo010747n
