6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine

Base Information

• Chemical Name: 6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine
• CAS No.: 29079-30-9
• Molecular Formula: C₁₆H₂₁NO
• Molecular Weight: 243.349
• Mol file: 29079-30-9.mol

Synonyms:6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine

Chemical Property of 6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine

There total 30 articles about 6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-(4-methoxyphenyl)-7-methyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one (104267-39-2) → 6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine (29079-30-9)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; Heating;

DOI:10.3987/COM-98-S(H)13

Reference yield:

2-(4-Methoxy-phenyl)-3-methyl-but-2-enoic acid ethyl ester (104267-37-0) → 6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine (29079-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) LDA, HMPA / 1.) THF, 2.) THF

2: 45 percent / BF₃*(C₂H₅)2O / CH₂Cl₂ / -78 - 20 °C

3: 73 percent / LiAlH₄-AlCl₃

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; aluminium trichloride; boron trifluoride diethyl etherate; lithium diisopropyl amide; In dichloromethane;

DOI:10.1021/jo00370a039

Reference yield:

tert-Butyl-[(E)-1-ethoxy-2-(4-methoxy-phenyl)-3-methyl-buta-1,3-dienyloxy]-dimethyl-silane (104267-38-1,104267-42-7) → 6-(4-methoxyphenyl)-7-methyl-1,2,3,5,8,8a-hexahydroindolizine (29079-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / BF₃*(C₂H₅)2O / CH₂Cl₂ / -78 - 20 °C

2: 73 percent / LiAlH₄-AlCl₃

With lithium aluminium tetrahydride; aluminium trichloride; boron trifluoride diethyl etherate; In dichloromethane;

DOI:10.1021/jo00370a039

upstream raw materials:

1-{1-[(E)-2-(4-Methoxy-phenyl)-vinyl]-pyrrolidin-2-yl}-propan-2-one

6-(4-methoxyphenyl)-7-methyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one

2-(4-Methoxy-phenyl)-1-[2-((E)-3-phenylsulfanyl-allyl)-pyrrolidin-1-yl]-ethanone

6-(4-methoxy-phenyl)-7-phenylsulfanylmethyl-hexahydro-indolizin-5-one

Downstream raw materials:

4-[7-methyl-1,2,3,5,8,8a-hexahydroindolizin-6-yl]phenol