1-{(3E)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane

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Chemical Name:1-{(3E)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane
CAS No.:641639-11-4
Molecular Formula:C₂₆H₃₄N₂OSSi
Molecular Weight:450.72
Hs Code.:

Synonyms:1-{(3E)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane

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Chemical Property of 1-{(3E)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane

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Technology Process of 1-{(3E)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane

There total 4 articles about 1-{(3E)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 120379-76-2
[3-[(tert-butyldimethylsilyl)oxy]propyl]triphenylphosphonium bromide

: 641639-09-0
[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]methanol

: 641639-10-3
1-{(3Z)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane

: 641639-11-4
1-{(3E)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane

Guidance literature:: With titanium(IV) isopropylate; manganese(IV) oxide; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; In tetrahydrofuran; for 5h; Heating;
DOI:10.1021/jm030276s

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 641639-11-4
1-{(3E)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / sodium methoxide / toluene / 2 h / 20 °C

2: 68 percent / methanol / 70 °C

3: 84 percent / LiAlH₄ / tetrahydrofuran / 20 °C

4: 6 percent / MnO₂; 1,3,4,6,7,8-hexahydro-1-methyl-2H-pyrimido[1,2-a]pyrimidine; Ti(i-OPr)4 / tetrahydrofuran / 5 h / Heating

With titanium(IV) isopropylate; manganese(IV) oxide; lithium aluminium tetrahydride; sodium methylate; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm030276s

Reference yield:

: 346684-15-9
methyl (2Z)-2-hydroxy-4-(4-methylthiophenyl)-4-oxobut-2-enoate

: 641639-11-4
1-{(3E)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / methanol / 70 °C

2: 84 percent / LiAlH₄ / tetrahydrofuran / 20 °C

3: 6 percent / MnO₂; 1,3,4,6,7,8-hexahydro-1-methyl-2H-pyrimido[1,2-a]pyrimidine; Ti(i-OPr)4 / tetrahydrofuran / 5 h / Heating

With titanium(IV) isopropylate; manganese(IV) oxide; lithium aluminium tetrahydride; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; In tetrahydrofuran; methanol;
DOI:10.1021/jm030276s