tert-butyl 3-chloro-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Chemical Name:tert-butyl 3-chloro-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
CAS No.:1400285-26-8
Molecular Formula:C₂₅H₂₆Cl₂N₆O₃
Molecular Weight:529.426
Hs Code.:

Synonyms:tert-butyl 3-chloro-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Chemical Property of tert-butyl 3-chloro-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Technology Process of tert-butyl 3-chloro-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

There total 12 articles about tert-butyl 3-chloro-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1019018-13-3
4-amino-3-chloro-N,N-dimethylbenzamide

: 1400287-18-4
tert-butyl 6-bromo-3-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

: 1400285-26-8
tert-butyl 3-chloro-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl acetamide; at 80 - 90 ℃;

Reference yield:

: 7598-35-8
2-bromo-4-aminopyridine

: 1400285-26-8
tert-butyl 3-chloro-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; sodium acetate; Iodine monochloride / 3 h / 75 °C

2.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

2.2: 1.75 h / 20 °C

3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 3 h / 50 °C / Inert atmosphere

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

5.1: triethylamine; dmap / N,N-dimethyl-formamide; ethyl acetate / 20 °C

6.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / N,N-dimethyl acetamide / 80 - 90 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-chloro-succinimide; copper(l) iodide; potassium tert-butylate; sodium acetate; Iodine monochloride; caesium carbonate; acetic acid; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1300750-78-0
4-amino-2-bromo-5-iodopyridine

: 1400285-26-8
tert-butyl 3-chloro-6-(2-chloro-4-(dimethylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

1.2: 1.75 h / 20 °C

2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 3 h / 50 °C / Inert atmosphere

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

4.1: triethylamine; dmap / N,N-dimethyl-formamide; ethyl acetate / 20 °C

5.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / N,N-dimethyl acetamide / 80 - 90 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-chloro-succinimide; copper(l) iodide; potassium tert-butylate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;