(+/-)-7-chloro-8-methoxy-3-<4-(N-carbobenzoxyamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:(+/-)-7-chloro-8-methoxy-3-<4-(N-carbobenzoxyamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:171285-48-6
Molecular Formula:C₂₉H₃₁ClN₂O₄
Molecular Weight:507.029
Hs Code.:

Synonyms:(+/-)-7-chloro-8-methoxy-3-<4-(N-carbobenzoxyamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of (+/-)-7-chloro-8-methoxy-3-<4-(N-carbobenzoxyamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of (+/-)-7-chloro-8-methoxy-3-<4-(N-carbobenzoxyamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 4 articles about (+/-)-7-chloro-8-methoxy-3-<4-(N-carbobenzoxyamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5105-78-2
4-(benzyloxycarbonylamino)butyric acid

: 73445-60-0
(+/-)-7-chloro-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 171285-48-6
(+/-)-7-chloro-8-methoxy-3-<4-(N-carbobenzoxyamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMF, 3 h, 2.) DMF, RT, 48 h;
DOI:10.1021/jm00021a018

Reference yield:

: 7569-87-1
3-chloro-4-methoxyphenethylamine

: 171285-48-6
(+/-)-7-chloro-8-methoxy-3-<4-(N-carbobenzoxyamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / tetrahydrofuran / 18 h / Heating

2: 95 percent / 99percent CF₃COOH, 99percent CH₃SO₃H / 18 h / Heating

3: 1.) 1-hydroxybenzotriazole hydrate, dicylohexylcarbodiimide, 2.) Et₃N / 1.) DMF, 3 h, 2.) DMF, RT, 48 h

With methanesulfonic acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm00021a018

Reference yield:

: 7569-58-6
2-(3-chloro-4-methoxyphenyl)acetonitrile

: 171285-48-6
(+/-)-7-chloro-8-methoxy-3-<4-(N-carbobenzoxyamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 1 h / Ambient temperature

2: 50 percent / tetrahydrofuran / 18 h / Heating

3: 95 percent / 99percent CF₃COOH, 99percent CH₃SO₃H / 18 h / Heating

4: 1.) 1-hydroxybenzotriazole hydrate, dicylohexylcarbodiimide, 2.) Et₃N / 1.) DMF, 3 h, 2.) DMF, RT, 48 h

With lithium aluminium tetrahydride; methanesulfonic acid; sulfuric acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm00021a018